The Role of Chromosome–Nuclear Envelope Attachments in 3D Genome Organization
- Authors: Sharakhov I.V.1,2, Bondarenko S.M.2, Artemov G.N.2, Onufriev A.V.3
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Affiliations:
- Virginia Polytechnic Institute and State University, Fralin Life Science Institute
- Tomsk State University, Laboratory of Ecology
- Virginia Polytechnic Institute and State University
- Issue: Vol 83, No 4 (2018)
- Pages: 350-358
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151628
- DOI: https://doi.org/10.1134/S0006297918040065
- ID: 151628
Cite item
Abstract
Chromosomes are intricately folded and packaged in the cell nucleus and interact with the nuclear envelope. This complex nuclear architecture has a profound effect on how the genome works and how the cells function. The main goal of review is to highlight recent studies on the effect of chromosome–nuclear envelope interactions on chromatin folding and function in the nucleus. The data obtained suggest that chromosome–nuclear envelope attachments are important for the organization of nuclear architecture in various organisms. A combination of experimental cell biology methods with computational modeling offers a unique opportunity to explore the fundamental relationships between different aspects of 3D genome organization in greater details. This powerful interdisciplinary approach could reveal how the organization and function of the genome in the nuclear space is affected by the chromosome–nuclear envelope attachments and will enable the development of novel approaches to regulate gene expression.
Keywords
About the authors
I. V. Sharakhov
Virginia Polytechnic Institute and State University, Fralin Life Science Institute; Tomsk State University, Laboratory of Ecology
Author for correspondence.
Email: igor@vt.edu
United States, Blacksburg, VA, 24061; Tomsk
S. M. Bondarenko
Tomsk State University, Laboratory of Ecology
Email: igor@vt.edu
Russian Federation, Tomsk
G. N. Artemov
Tomsk State University, Laboratory of Ecology
Email: igor@vt.edu
Russian Federation, Tomsk
A. V. Onufriev
Virginia Polytechnic Institute and State University; Virginia Polytechnic Institute and State University
Email: igor@vt.edu
United States, Blacksburg, VA, 24060; Blacksburg, VA, 24061
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