The Role of Chromosome–Nuclear Envelope Attachments in 3D Genome Organization
- 作者: Sharakhov I.1,2, Bondarenko S.2, Artemov G.2, Onufriev A.3
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隶属关系:
- Virginia Polytechnic Institute and State University, Fralin Life Science Institute
- Tomsk State University, Laboratory of Ecology
- Virginia Polytechnic Institute and State University
- 期: 卷 83, 编号 4 (2018)
- 页面: 350-358
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151628
- DOI: https://doi.org/10.1134/S0006297918040065
- ID: 151628
如何引用文章
详细
Chromosomes are intricately folded and packaged in the cell nucleus and interact with the nuclear envelope. This complex nuclear architecture has a profound effect on how the genome works and how the cells function. The main goal of review is to highlight recent studies on the effect of chromosome–nuclear envelope interactions on chromatin folding and function in the nucleus. The data obtained suggest that chromosome–nuclear envelope attachments are important for the organization of nuclear architecture in various organisms. A combination of experimental cell biology methods with computational modeling offers a unique opportunity to explore the fundamental relationships between different aspects of 3D genome organization in greater details. This powerful interdisciplinary approach could reveal how the organization and function of the genome in the nuclear space is affected by the chromosome–nuclear envelope attachments and will enable the development of novel approaches to regulate gene expression.
作者简介
I. Sharakhov
Virginia Polytechnic Institute and State University, Fralin Life Science Institute; Tomsk State University, Laboratory of Ecology
编辑信件的主要联系方式.
Email: igor@vt.edu
美国, Blacksburg, VA, 24061; Tomsk
S. Bondarenko
Tomsk State University, Laboratory of Ecology
Email: igor@vt.edu
俄罗斯联邦, Tomsk
G. Artemov
Tomsk State University, Laboratory of Ecology
Email: igor@vt.edu
俄罗斯联邦, Tomsk
A. Onufriev
Virginia Polytechnic Institute and State University; Virginia Polytechnic Institute and State University
Email: igor@vt.edu
美国, Blacksburg, VA, 24060; Blacksburg, VA, 24061
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