The Role of Chromosome–Nuclear Envelope Attachments in 3D Genome Organization
- Авторлар: Sharakhov I.1,2, Bondarenko S.2, Artemov G.2, Onufriev A.3
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Мекемелер:
- Virginia Polytechnic Institute and State University, Fralin Life Science Institute
- Tomsk State University, Laboratory of Ecology
- Virginia Polytechnic Institute and State University
- Шығарылым: Том 83, № 4 (2018)
- Беттер: 350-358
- Бөлім: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151628
- DOI: https://doi.org/10.1134/S0006297918040065
- ID: 151628
Дәйексөз келтіру
Аннотация
Chromosomes are intricately folded and packaged in the cell nucleus and interact with the nuclear envelope. This complex nuclear architecture has a profound effect on how the genome works and how the cells function. The main goal of review is to highlight recent studies on the effect of chromosome–nuclear envelope interactions on chromatin folding and function in the nucleus. The data obtained suggest that chromosome–nuclear envelope attachments are important for the organization of nuclear architecture in various organisms. A combination of experimental cell biology methods with computational modeling offers a unique opportunity to explore the fundamental relationships between different aspects of 3D genome organization in greater details. This powerful interdisciplinary approach could reveal how the organization and function of the genome in the nuclear space is affected by the chromosome–nuclear envelope attachments and will enable the development of novel approaches to regulate gene expression.
Негізгі сөздер
Авторлар туралы
I. Sharakhov
Virginia Polytechnic Institute and State University, Fralin Life Science Institute; Tomsk State University, Laboratory of Ecology
Хат алмасуға жауапты Автор.
Email: igor@vt.edu
АҚШ, Blacksburg, VA, 24061; Tomsk
S. Bondarenko
Tomsk State University, Laboratory of Ecology
Email: igor@vt.edu
Ресей, Tomsk
G. Artemov
Tomsk State University, Laboratory of Ecology
Email: igor@vt.edu
Ресей, Tomsk
A. Onufriev
Virginia Polytechnic Institute and State University; Virginia Polytechnic Institute and State University
Email: igor@vt.edu
АҚШ, Blacksburg, VA, 24060; Blacksburg, VA, 24061
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