Extracellular actin in health and disease
- Authors: Sudakov N.P.1,2,3,4, Klimenkov I.V.3,4, Byvaltsev V.A.1, Nikiforov S.B.1, Konstantinov Y.M.3,5
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Affiliations:
- Irkutsk Surgery and Traumatology Research Center
- Irkutsk Research Center
- Irkutsk State University
- Limnological Institute
- Siberian Institute of Plant Physiology and Biochemistry
- Issue: Vol 82, No 1 (2017)
- Pages: 1-12
- Section: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151210
- DOI: https://doi.org/10.1134/S0006297917010011
- ID: 151210
Cite item
Abstract
This review considers the functions of extracellular actin–cell surface bound, associated with extracellular matrix, or freely circulating. The role of this protein in different pathological processes is analyzed: its toxic effects and involvement in autoimmune diseases as an autoantigen. The extracellular actin clearance system and its role in protection against the negative effects of actin are characterized. Levels of free-circulating actin, anti-actin immunoglobulins, and components of the actin clearance system as prognostic biomarkers for different diseases are reviewed. Experimental approaches to protection against excessive amounts of free-circulating F-actin are discussed.
About the authors
N. P. Sudakov
Irkutsk Surgery and Traumatology Research Center; Irkutsk Research Center; Irkutsk State University; Limnological Institute
Email: yukon@sifibr.irk.ru
Russian Federation, Irkutsk, 664003; Irkutsk, 664033; Irkutsk, 664003; Irkutsk, 664033
I. V. Klimenkov
Irkutsk State University; Limnological Institute
Email: yukon@sifibr.irk.ru
Russian Federation, Irkutsk, 664003; Irkutsk, 664033
V. A. Byvaltsev
Irkutsk Surgery and Traumatology Research Center
Email: yukon@sifibr.irk.ru
Russian Federation, Irkutsk, 664003
S. B. Nikiforov
Irkutsk Surgery and Traumatology Research Center
Email: yukon@sifibr.irk.ru
Russian Federation, Irkutsk, 664003
Yu. M. Konstantinov
Irkutsk State University; Siberian Institute of Plant Physiology and Biochemistry
Author for correspondence.
Email: yukon@sifibr.irk.ru
Russian Federation, Irkutsk, 664003; Irkutsk, 664033