Extracellular actin in health and disease
- Autores: Sudakov N.1,2,3,4, Klimenkov I.3,4, Byvaltsev V.1, Nikiforov S.1, Konstantinov Y.3,5
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Afiliações:
- Irkutsk Surgery and Traumatology Research Center
- Irkutsk Research Center
- Irkutsk State University
- Limnological Institute
- Siberian Institute of Plant Physiology and Biochemistry
- Edição: Volume 82, Nº 1 (2017)
- Páginas: 1-12
- Seção: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151210
- DOI: https://doi.org/10.1134/S0006297917010011
- ID: 151210
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Resumo
This review considers the functions of extracellular actin–cell surface bound, associated with extracellular matrix, or freely circulating. The role of this protein in different pathological processes is analyzed: its toxic effects and involvement in autoimmune diseases as an autoantigen. The extracellular actin clearance system and its role in protection against the negative effects of actin are characterized. Levels of free-circulating actin, anti-actin immunoglobulins, and components of the actin clearance system as prognostic biomarkers for different diseases are reviewed. Experimental approaches to protection against excessive amounts of free-circulating F-actin are discussed.
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Sobre autores
N. Sudakov
Irkutsk Surgery and Traumatology Research Center; Irkutsk Research Center; Irkutsk State University; Limnological Institute
Email: yukon@sifibr.irk.ru
Rússia, Irkutsk, 664003; Irkutsk, 664033; Irkutsk, 664003; Irkutsk, 664033
I. Klimenkov
Irkutsk State University; Limnological Institute
Email: yukon@sifibr.irk.ru
Rússia, Irkutsk, 664003; Irkutsk, 664033
V. Byvaltsev
Irkutsk Surgery and Traumatology Research Center
Email: yukon@sifibr.irk.ru
Rússia, Irkutsk, 664003
S. Nikiforov
Irkutsk Surgery and Traumatology Research Center
Email: yukon@sifibr.irk.ru
Rússia, Irkutsk, 664003
Yu. Konstantinov
Irkutsk State University; Siberian Institute of Plant Physiology and Biochemistry
Autor responsável pela correspondência
Email: yukon@sifibr.irk.ru
Rússia, Irkutsk, 664003; Irkutsk, 664033