Extracellular actin in health and disease
- 作者: Sudakov N.1,2,3,4, Klimenkov I.3,4, Byvaltsev V.1, Nikiforov S.1, Konstantinov Y.3,5
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隶属关系:
- Irkutsk Surgery and Traumatology Research Center
- Irkutsk Research Center
- Irkutsk State University
- Limnological Institute
- Siberian Institute of Plant Physiology and Biochemistry
- 期: 卷 82, 编号 1 (2017)
- 页面: 1-12
- 栏目: Review
- URL: https://journals.rcsi.science/0006-2979/article/view/151210
- DOI: https://doi.org/10.1134/S0006297917010011
- ID: 151210
如何引用文章
详细
This review considers the functions of extracellular actin–cell surface bound, associated with extracellular matrix, or freely circulating. The role of this protein in different pathological processes is analyzed: its toxic effects and involvement in autoimmune diseases as an autoantigen. The extracellular actin clearance system and its role in protection against the negative effects of actin are characterized. Levels of free-circulating actin, anti-actin immunoglobulins, and components of the actin clearance system as prognostic biomarkers for different diseases are reviewed. Experimental approaches to protection against excessive amounts of free-circulating F-actin are discussed.
作者简介
N. Sudakov
Irkutsk Surgery and Traumatology Research Center; Irkutsk Research Center; Irkutsk State University; Limnological Institute
Email: yukon@sifibr.irk.ru
俄罗斯联邦, Irkutsk, 664003; Irkutsk, 664033; Irkutsk, 664003; Irkutsk, 664033
I. Klimenkov
Irkutsk State University; Limnological Institute
Email: yukon@sifibr.irk.ru
俄罗斯联邦, Irkutsk, 664003; Irkutsk, 664033
V. Byvaltsev
Irkutsk Surgery and Traumatology Research Center
Email: yukon@sifibr.irk.ru
俄罗斯联邦, Irkutsk, 664003
S. Nikiforov
Irkutsk Surgery and Traumatology Research Center
Email: yukon@sifibr.irk.ru
俄罗斯联邦, Irkutsk, 664003
Yu. Konstantinov
Irkutsk State University; Siberian Institute of Plant Physiology and Biochemistry
编辑信件的主要联系方式.
Email: yukon@sifibr.irk.ru
俄罗斯联邦, Irkutsk, 664003; Irkutsk, 664033