Clinical case of fulminant course of atypical hemolytic-uremic syndrome

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Abstract

This clinical observation describes a case of a fulminant course of an atypical hemolytic-uremic syndrome. The initial stage of the course of the disease is of particular interest, which was not accompanied by typical manifestations of atypical hemolytic-uremic syndrome according to the type of acquired autoimmune hemolytic anemia. Thus, revealing this clinical observation may help in the diagnosis of atypical hemolytic-uremic syndrome with atypical initial manifestations and avoid errors, delays and adverse outcomes of this disease.

About the authors

Georgy A. Rysev

Saint Petersburg Research Institute of Emergency Medicine named after. I.I. Dzhanelidze

Author for correspondence.
Email: rysevszgmu@inbox.ru
SPIN-code: 1966-3919
Russian Federation, Saint Petersburg

Alexander V. Rysev

Saint Petersburg Research Institute of Emergency Medicine named after. I.I. Dzhanelidze; North-Western State Medical University named after I.I. Mechnikov

Email: 79213221618@yandex.ru
SPIN-code: 7715-0455

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, Saint Petersburg; Saint Petersburg

Elena V. Karyagina

Saint Petersburg City Clinical Hospital No. 15

Email: rysevszgmu@inbox.ru
SPIN-code: 8158-0620

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Nadezhda V. Medvedeva

Saint Petersburg City Oncohematology Center, City Clinical Hospital No. 31

Email: or@hpmp.ru

MD, Cand. Sci. (Med.)

Russian Federation, Saint Petersburg

Vadim I. Mazurov

North-Western State Medical University named after I.I. Mechnikov

Email: maz.nwgmu@yandex.ru
ORCID iD: 0000-0002-0797-2051
SPIN-code: 6823-5482

MD, Dr. Sci. (Med.), Professor, Academician of the RAS, Honored Scientist of the Russian Federation

Russian Federation, Saint Petersburg

References

  1. Atipichnyi gemolitiko-uremicheskii sindrom u vzroslykh. Klinicheskie rekomendatsii. [Internet]. Available from: https://rusnephrology.org/wp-content/uploads/2021/09/ahus.pdf. Accessed: 16.09.2023. (In Russ.)
  2. Laurence J, Haller H, Mannucci PM, et al. Atypical hemolytic uremic syndrome (aHUS): essential aspects of an accurate diagnosis. Clin Adv Hematol Oncol. 2016;14 Suppl 11(11):2–15.
  3. The portal for rare diseases and orphan drugs. [Internet]. Available from: https://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=779&Disease_Disease_Search_diseaseGroup=aHUS&Disease_Disease_Search_diseaseType=Pat&Disease%28s%29/group%20of%20disease. Accessed: 16.09.2023.

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