Outcomes of the New COVID-19 Coronavirus Infection in 68 Patients with Inflammatory Bowel Diseases
- 作者: Kagramanova A.V.1, Knyazev O.V.1,2,3, Veselov A.V.2, Shkurko T.V.2, Li I.A.1, Fadeeva N.A.1, Kulakov D.S.1,2, Lishchinskaya A.A.1, Zvyaglova M.Y.1, Chernova M.E.1, Parfenov A.I.1
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隶属关系:
- Moscow Clinical Scientific Center Named after A.S. Loginov
- Research Institute of Health Organization and Medical Management
- State Scientific Centre of Coloproctology
- 期: 卷 75, 编号 5S (2020)
- 页面: 406-413
- 栏目: INFECTIOUS DISEASES: CURRENT ISSUES
- URL: https://journals.rcsi.science/vramn/article/view/125717
- DOI: https://doi.org/10.15690/vramn1423
- ID: 125717
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Background. COVID-19 is an infectious respiratory syndrome with a wide range of manifestations and outcomes. Patients with inflammatory bowel disease (IBD) generally have a higher risk of infection, especially if they receive immunosuppressive therapy.
Aim — to describe the manifestations of COVID-19 in patients with IBD and to determine the risk factors for severe COVID-19.
Methods. The analysis included 68 patients with an established diagnosis of Crohn’s disease (CD) or ulcerative colitis and a confirmed new coronavirus infection. The diagnosis of coronavirus infection was established when SARS-CoV-2 was detected by PCR using nasopharyngeal smears, and computer tomography (CT) of the chest revealed inflammatory changes characteristic of coronavirus lung damage or high IgG and IgM titers based on the results of immunological blood analysis.
Results. 68 patients with IBD and COVID-19 were observed in the Department of IBD, including 27 (39.7%) patients with CD, 41 (60.3%) patients with UC. Among patients diagnosed with pneumonia, 100 % of patients received therapy with thiopurines and infliximab. 8 (11.8%) patients were diagnosed with COVID-19 during hospitalization for a severe IBD attack. There was no statistically significant difference between UC and CD patients in terms of disease activity (p = 0.13) during the period of coronavirus infection. In 37 patients (26 — UC, 11 — BC) with pneumonia (100%), there was an exacerbation of IBD. Statistical significance was found between the development of more severe lung damage (CT 3–4) and IBD activity at the time of diagnosis of COVID-19 (p < 0.001), the presence of comorbidities (p < 0.001) and taking GCS (p < 0.001) at the time of detection of COVID-19. However, the use of biological and immunosuppressive therapy was not associated with a higher risk of severe lung damage and the need for a ventilator. It was shown that the age of patients over 65 years was statistically correlated with the need for a ventilator (p = 0.02).
Conclusion. The exacerbation of the disease, especially in elderly patients with comorbidities, the use of glucocorticosteroids was associated with negative consequences of COVID-19, while biological and immunosuppressant drugs used for the treatment of IBD did not have such a negative effect.
作者简介
Anna Kagramanova
Moscow Clinical Scientific Center Named after A.S. Loginov
Email: kagramanova@me.com
ORCID iD: 0000-0002-3818-6205
SPIN 代码: 4086-6745
MD, PhD, Senior Research Associate
俄罗斯联邦, 86 Shosse Entuziastov, 111123, MoscowOleg Knyazev
Moscow Clinical Scientific Center Named after A.S. Loginov; Research Institute of Health Organization and Medical Management; State Scientific Centre of Coloproctology
编辑信件的主要联系方式.
Email: oleg7@bk.ru
ORCID iD: 0000-0001-7250-0977
SPIN 代码: 3268-0360
MD, PhD, Leading Research Associate
俄罗斯联邦, Moscow; Moscow; MoscowAlexei Veselov
Research Institute of Health Organization and Medical Management
Email: a_veselov82@mail.ru
ORCID iD: 0000-0003-3115-1787
SPIN 代码: 9333-8673
MD, PhD, Leading Research Associate
俄罗斯联邦, MoscowTatyana Shkurko
Research Institute of Health Organization and Medical Management
Email: 89165457033@mail.ru
ORCID iD: 0000-0002-7502-2437
SPIN 代码: 9073-3362
PhD
俄罗斯联邦, MoscowIrina Li
Moscow Clinical Scientific Center Named after A.S. Loginov
Email: i.li@mknc.ru
ORCID iD: 0000-0002-9508-7502
SPIN 代码: 6336-3049
PhD
俄罗斯联邦, MoscowNina Fadeeva
Moscow Clinical Scientific Center Named after A.S. Loginov
Email: chuevana@mail.ru
ORCID iD: 0000-0002-0524-2514
SPIN 代码: 6047-7590
MD, PhD, Senior Research Associate
俄罗斯联邦, MoscowDmitriy Kulakov
Moscow Clinical Scientific Center Named after A.S. Loginov; Research Institute of Health Organization and Medical Management
Email: dm.kulakov77@gmail.com
ORCID iD: 0000-0002-0855-5217
SPIN 代码: 9966-0006
Junior Research Associate
俄罗斯联邦, Moscow; MoscowAlbina Lishchinskaya
Moscow Clinical Scientific Center Named after A.S. Loginov
Email: lalbina@inbox.ru
ORCID iD: 0000-0001-7891-2702
SPIN 代码: 9369-9674
MD, PhD, Senior Research Associate
俄罗斯联邦, MoscowMariya Zvyaglova
Moscow Clinical Scientific Center Named after A.S. Loginov
Email: zwmr306@mail.ru
ORCID iD: 0000-0002-7937-2346
SPIN 代码: 6119-5774
Junior Research Associate
俄罗斯联邦, MoscowMarina Chernova
Moscow Clinical Scientific Center Named after A.S. Loginov
Email: m.chernova@mknc.ru
ORCID iD: 0000-0002-6127-1723
SPIN 代码: 1053-0790
MD, PhD
俄罗斯联邦, MoscowAsfold Parfenov
Moscow Clinical Scientific Center Named after A.S. Loginov
Email: asfold@mail.ru
ORCID iD: 0000-0002-9782-4860
SPIN 代码: 5142-3632
MD, PhD, Professor
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