Extracellular neutrophil traps (NETs) in the pathogenesis of thrombosis and thromboinflammation


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This article summarizes numerous studies on the relationship of biological processes such as inflammation and thrombosis. The huge role of neutrophils and the extracellular neutrophil traps (NETs) secreted by them has been demonstrated. The discovery of NETs has opened new horizons in the understanding of neutrophil biology and the role of these cells in the body. The use of chromatin in combination with the intracellular proteins, as an effective antimicrobial agent has ancient roots and changes our understanding of chromatin only as a carrier of genetic information. Through NETs, neutrophils can contribute to the development of pathological venous and arterial thrombosis or “immunothrombosis”, as well as atherosclerosis. NETs release has been shown to be one of the causes of thrombosis in conditions such as sepsis and cancer. The presence of NETs in these diseases and conditions makes it possible to use them or individual components as potential biomarkers. NETs and their components may be attractive as therapeutic targets. Further studies of neutrophils and NETs are needed to develop new approaches to the diagnosis and treatment of inflammatory and thrombotic conditions. Perhaps long-forgotten drugs will find a new area for effective use.

作者简介

Victoria Bitsadze

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: vikabits@mail.ru
ORCID iD: 0000-0001-8404-1042
SPIN 代码: 5930-0859

MD, PhD, Professor

俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992

Ekaterina Slukhanchuk

Petrovsky National Research Center of Surgery

Email: beloborodova@rambler.ru
ORCID iD: 0000-0001-7441-2778
SPIN 代码: 7423-8944

MD, PhD, Assistant Professor

俄罗斯联邦, 2, Abrikosovsky pereulok, Moscow, 119991

Jamilya Khizroeva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: jamatotu@gmail.com
ORCID iD: 0000-0002-0725-9686
SPIN 代码: 8225-4976
Scopus 作者 ID: 57194547147
Researcher ID: F-8384-2017

MD, PhD, Professor

俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992

Maria Tretyakova

The First I.M. Sechenov Moscow State Medical University (Sechenov University); Medical Center LLC

Email: tretyakova777@yandex.ru
ORCID iD: 0000-0002-3628-0804
SPIN 代码: 1463-0065

MD, PhD, Assistant Professor

俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992; Timura Frunze str.15/1, 119021, Moscow

Andrei Shkoda

L.A. Vorokhobov City Clinical Hospital Sixty-seven

Email: 67gkb@mail.ru
ORCID iD: 0000-0002-9783-1796

MD, PhD, Professor

俄罗斯联邦, 2/44, Salyama Adilya str., Moscow, 123423

Liudmila Radetskaya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: udaeva@gmail.com
ORCID iD: 0000-0003-3410-6885
SPIN 代码: 4554-7324

MD, Associated Professor

俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992

Alexander Makatsariya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

编辑信件的主要联系方式.
Email: gemostasis@mail.ru
ORCID iD: 0000-0001-7415-4633
SPIN 代码: 7538-2966
https://internist.ru/lectors/detail/makatsariya-/

MD, PhD, Academician of the RAS

俄罗斯联邦, 8-2, Trubetskaya street, Moscow, 119992

Ismail Elalamy

I.M. Sechenov Moscow State Medical University (Sechenov University); Medicine Sorbonne University, University Hospital Tenon

Email: ismail.elalamy@aphp.fr
ORCID iD: 0000-0002-9576-1368
Scopus 作者 ID: 7003652413

MD, PhD, Professor

俄罗斯联邦, Trubetskaya str. 8-2, 119991; rue de la Chine 75970 Paris Cédex 20, France

Jean-Christophe Gris

I.M. Sechenov First Moscow State Medical University (Sechenov University); University Montpellier, France

Email: jean.christophe.gris@chu-nimes.fr
ORCID iD: 0000-0002-9899-9910
Scopus 作者 ID: 7005114260

MD, PhD, Professor

俄罗斯联邦, Trubetskaya str. 8-2, 119991, Moscow; Place du Pr. Robert Debré 30039 Nîmes cédex 09

Elvira Grandone

The First I.M. Sechenov Moscow State Medical University, (Sechenov University);
Thrombosis and Haemostasis Research Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza"

Email: grandoneelvira@gmail.com
ORCID iD: 0000-0002-8980-9783
Scopus 作者 ID: 7006391091

MD, PhD, Professor, Department of thrombosis and hemostasis

意大利, Trubetskaya str. 8-2, 119991, Moscow; 71043, Viale Padre Pio, San Giovanni Rotondo, Foggia, Italy

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