Features of the microenvironment of oncourological tumors
- 作者: Molchanov O.1, Maistrenko D.1, Granov D.1, Lisitsin I.1, Romanov A.1,2
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隶属关系:
- A.M. Granov Russian Research Center of Radiology and Surgical Technologies
- Sortavala Central District Hospital
- 期: 卷 12, 编号 4 (2022)
- 页面: 313-331
- 栏目: Reviews
- URL: https://journals.rcsi.science/uroved/article/view/134234
- DOI: https://doi.org/10.17816/uroved112576
- ID: 134234
如何引用文章
详细
The interaction of tumor cells, especially if they are stem or resting, with myeloid and lymphoid components, as well as extracellular matrix producers, leads to the formation of a pathological microenvironment that causes resistance to many systemic treatment options. The aim of the work is to present modern literature and own data concerning the features of the composition and structure of the microenvironment in tumors of the kidney, prostate and bladder. The article presents data on the composition and interaction of various subpopulations of cells in the tumor microenvironment, as well as on the role of stem tumor cells in its formation. Defects of signaling pathways of stem tumor cells are described, as well as the mechanism of interaction between the tumor and the immune system in the process of carcinogenesis. Approaches to the assessment of the type of microenvironment for the purpose of individualization of treatment are analyzed in detail. The authors present their own data on the nature of the distribution of subpopulations of lymphocytes and suppressor cells of myeloid origin in patients with metastatic forms of tumors of the genitourinary tract. The variants of using data on the structure of the microenvironment in order to optimize treatment tactics in cancer patients are indicated.
作者简介
Oleg Molchanov
A.M. Granov Russian Research Center of Radiology and Surgical Technologies
编辑信件的主要联系方式.
Email: molchanovo@mail.ru
ORCID iD: 0000-0003-3882-1720
SPIN 代码: 5557-6468
Scopus 作者 ID: 25637650600
Researcher ID: AAX-2364-2020
Dr. Sci. (Med.), Head of Department of Fundamental Investigations
俄罗斯联邦, Pesochnyi village, Saint PetersburgDmitriy Maistrenko
A.M. Granov Russian Research Center of Radiology and Surgical Technologies
Email: may64@mail.ru
ORCID iD: 0000-0001-8174-7461
SPIN 代码: 7363-4840
Scopus 作者 ID: 57193120885
Researcher ID: AAA-9446-2020
Dr. Sci. (Med.), Director
俄罗斯联邦, Pesochnyi village, Saint PetersburgDmitriy Granov
A.M. Granov Russian Research Center of Radiology and Surgical Technologies
Email: da_granov@rrcrst.ru
ORCID iD: 0000-0002-8746-8452
SPIN 代码: 5256-2744
Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Scientific Adviser
俄罗斯联邦, Pesochnyi village, Saint PetersburgIgor Lisitsin
A.M. Granov Russian Research Center of Radiology and Surgical Technologies
Email: urologlis@mail.ru
Cand. Sci. (Med.), Urologist, Head of the Outpatient Consultation Center
俄罗斯联邦, Pesochnyi village, Saint PetersburgAlexandr Romanov
A.M. Granov Russian Research Center of Radiology and Surgical Technologies; Sortavala Central District Hospital
Email: tiffozi@mail.ru
Research Associate; Chief Physician
俄罗斯联邦, Pesochnyi village, Saint Petersburg; Sortavala Republic of Karelia参考
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