Predictive value of inflammatory indices LMR, PLR and NLR in patients with muscle-invasive bladder cancer
- Authors: Gorelov A.I.1,2, Zhuravskii D.A.3, Gorelova A.A.3,4
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Affiliations:
- Saint Petersburg State University
- City Pokrovskaya Hospital
- Saint-Petersburg University
- St. Petersburg Research Institute of Phthisiopulmonology
- Issue: Vol 11, No 4 (2021)
- Pages: 285-294
- Section: Original articles
- URL: https://journals.rcsi.science/uroved/article/view/83815
- DOI: https://doi.org/10.17816/uroved83815
- ID: 83815
Cite item
Abstract
BACKGROUND: Increasing the efficiency of predicting the results of treatment of patients with bladder cancer is one of the important tasks of modern urology.
AIM: Our aim was to identify and evaluate the association between the most significant clinical, morphological and immunological markers and survival of muscle-invasive bladder cancer patients treated with radical cystectomy. We also developed an algorithm for diagnosis and treatment of patients with muscle-invasive bladder cancer.
MATERIALS AND METHODS: This retrospective study included 100 muscle-invasive bladder cancer patients, who underwent radical cystectomy between 1995 and 2013. The study endpoints were overall survival.
RESULTS: Univariable analysis revealed that continuous (Lymphocyte-monocyte ratio), PLR (platelet-lymphocyte ratio) и NLR (neutrophil-lymphocyte ratio) were significantly associated with overall survival. On multivariable regression model analysis, continuous LMR, NLR, and PLR independently predicted both endpoints.
CONCLUSIONS: Our findings indicate that the cheap and simple blood-based biomarkers may be valuable in identifying muscle-invasive bladder cancer patients treated with radical cystectomy, who are at higher risk of all-cause mortality.
Keywords
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##article.viewOnOriginalSite##About the authors
Andrei I. Gorelov
Saint Petersburg State University; City Pokrovskaya Hospital
Email: gorelov_a_i@mail.ru
ORCID iD: 0000-0002-2858-5317
SPIN-code: 5070-9526
Scopus Author ID: 7005253173
https://med.spbu.ru/prepodavateli/913-gorelov-andrej-igorevich.html
Dr. Sci. (Med.), Professor of the Department of Hospital Surgery with a Course of Urology, Head of Urological Unit
Russian Federation, Saint Petersburg; Saint PetersburgDmitriy A. Zhuravskii
Saint-Petersburg University
Email: zhuravskiy.spbu@gmail.com
ORCID iD: 0000-0002-2556-3390
SPIN-code: 3748-7129
Postgraduate student
Russian Federation, Saint PetersburgAnna A. Gorelova
Saint-Petersburg University; St. Petersburg Research Institute of Phthisiopulmonology
Author for correspondence.
Email: gorelovauro@gmail.com
ORCID iD: 0000-0002-7010-7562
SPIN-code: 8568-9004
Scopus Author ID: 57202812074
Cand. Sci. (Med.), Assistant Professor of the Department of Hospital Surgery with a Course of Urology
Russian Federation, Saint-Petersburg; Saint-PetersburgReferences
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