Predictive value of inflammatory indices LMR, PLR and NLR in patients with muscle-invasive bladder cancer

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Abstract

BACKGROUND: Increasing the efficiency of predicting the results of treatment of patients with bladder cancer is one of the important tasks of modern urology.

AIM: Our aim was to identify and evaluate the association between the most significant clinical, morphological and immunological markers and survival of muscle-invasive bladder cancer patients treated with radical cystectomy. We also developed an algorithm for diagnosis and treatment of patients with muscle-invasive bladder cancer.

MATERIALS AND METHODS: This retrospective study included 100 muscle-invasive bladder cancer patients, who underwent radical cystectomy between 1995 and 2013. The study endpoints were overall survival.

RESULTS: Univariable analysis revealed that continuous (Lymphocyte-monocyte ratio), PLR (platelet-lymphocyte ratio) и NLR (neutrophil-lymphocyte ratio) were significantly associated with overall survival. On multivariable regression model analysis, continuous LMR, NLR, and PLR independently predicted both endpoints.

CONCLUSIONS: Our findings indicate that the cheap and simple blood-based biomarkers may be valuable in identifying muscle-invasive bladder cancer patients treated with radical cystectomy, who are at higher risk of all-cause mortality.

About the authors

Andrei I. Gorelov

Saint Petersburg State University; City Pokrovskaya Hospital

Email: gorelov_a_i@mail.ru
ORCID iD: 0000-0002-2858-5317
SPIN-code: 5070-9526
Scopus Author ID: 7005253173
https://med.spbu.ru/prepodavateli/913-gorelov-andrej-igorevich.html

Dr. Sci. (Med.), Professor of the Department of Hospital Surgery with a Course of Urology, Head of Urological Unit

Russian Federation, Saint Petersburg; Saint Petersburg

Dmitriy A. Zhuravskii

Saint-Petersburg University

Email: zhuravskiy.spbu@gmail.com
ORCID iD: 0000-0002-2556-3390
SPIN-code: 3748-7129

Postgraduate student

Russian Federation, Saint Petersburg

Anna A. Gorelova

Saint-Petersburg University; St. Petersburg Research Institute of Phthisiopulmonology

Author for correspondence.
Email: gorelovauro@gmail.com
ORCID iD: 0000-0002-7010-7562
SPIN-code: 8568-9004
Scopus Author ID: 57202812074

Cand. Sci. (Med.), Assistant Professor of the Department of Hospital Surgery with a Course of Urology

Russian Federation, Saint-Petersburg; Saint-Petersburg

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2. Fig. 1. ROC curve for overall survival of patients with muscle-invasive bladder cancer

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3. Fig. 2. Cumulative overall survival of patients with muscle-invasive bladder cancer at different values of inflammatory indices: а – overall survival of patients with high and low risk NLR (<0.0001); b – overall survival of patients with high and low risk PLR (<0.0001); с – overall survival of patients with high and low risk LMR (<0.0001)

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4. Fig. 1. ROC curve for overall survival of patients with muscle-invasive bladder cancer

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5. Fig. 2. Cumulative overall survival of patients with muscle-invasive bladder cancer at different values of inflammatory indices: а – overall survival of patients with high and low risk NLR (<0.0001); b – overall survival of patients with high and low risk PLR (<0.0001); с – overall survival of patients with high and low risk LMR (<0.0001)

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Copyright (c) 2021 Gorelov A.I., Zhuravskii D.A., Gorelova A.A.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


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