Email this article Renal function, endotoxicosis, and oxidative stress in patients after open and laparoscopic nephrectomy
- Authors: Popov S.V.1,2, Guseinov R.G.1,3, Sivak K.V.1,4, Perepelitsa V.V.1, Bunenkov N.S.1,5,6, Ulitina A.S.1,5
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Affiliations:
- Clinical Hospital of St. Luke
- Kirov Military Medical Academy
- Saint Petersburg State University
- Smorodintsev Research Institute of Influenza
- Academician I.P. Pavlov First St. Petersburg State Medical University
- Almazov National Medical Research Centre
- Issue: Vol 13, No 1 (2023)
- Pages: 71-78
- Section: Original articles
- URL: https://journals.rcsi.science/uroved/article/view/134246
- DOI: https://doi.org/10.17816/uroved119542
- ID: 134246
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Abstract
BACKGROUND: Renal cell cancer is accompanied by the development of a disorder of renal function. The parameters of homeostasis after nephrectomy in renal cell cancer are not well understood.
AIM: The aim of the study is to compare the kidney functional status and parameters of homeostasis in patients with RCC after nephrectomy performed by open and laparoscopic surgery.
MATERIALS AND METHODS: Eighty patients with renal cell cancer Т3N0M0 were randomized according to the surgery into the comparison group with open nephrectomy (n = 40; 50,1 ± 3,4 years old; 18 males, 22 females) and the main group with laparoscopic nephrectomy (n = 40; 52,4 ± 5,1 years old; 16 males, 24 females). The control group was comprises from twenty subjects without urological pathology, 22–58 years old, 10 males, 10 females. Laboratory parameters of endotoxicosis, lipid peroxidation, kidney functional status, partial kidney functions, and urinary syndrome were assessed on the 1st, 3rd, 6th and 10th days after the surgery.
RESULTS: The early postoperative period of nephrectomy in renal cell cancer is accompanied by the development of endotoxicosis, activation of lipid peroxidation, deterioration of the functional state of the remaining kidney, and the formation of chronic kidney disease. At the same time, both systemic indicators (toxicity index, as well as concentrations of medium-weight molecules, diene conjugates, malondialdehyde), and renal parameters (glomerular filtration rate, albumin-creatinine ratio) are associated with the method of surgery: with a laparoscopic approach, changes in these indicators are reversible and less pronounced than with open nephrectomy.
CONCLUSIONS: The present study demonstrates the advantage of laparoscopic nephrectomy compared to open nephrectomy in patients with renal cell cancer.
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##article.viewOnOriginalSite##About the authors
Sergey V. Popov
Clinical Hospital of St. Luke; Kirov Military Medical Academy
Email: doc.popov@gmail.com
ORCID iD: 0000-0003-2767-7153
SPIN-code: 3830-9539
Doc. Sci. (Med.), urologist
Russian Federation, Saint Petersburg; Saint PetersburgRuslan G. Guseinov
Clinical Hospital of St. Luke; Saint Petersburg State University
Author for correspondence.
Email: rusfa@yandex.ru
ORCID iD: 0000-0001-9935-0243
SPIN-code: 4222-4601
Scopus Author ID: 57209859097
Cand. Sci. (Med.)
Russian Federation, Saint Petersburg; Saint PetersburgKonstantin V. Sivak
Clinical Hospital of St. Luke; Smorodintsev Research Institute of Influenza
Email: kvsivak@gmail.com
ORCID iD: 0000-0003-4064-5033
SPIN-code: 7426-8322
Dr. Sci. (Biol.), leading research associate
Russian Federation, Saint Petersburg; Saint PetersburgVitaliy V. Perepelitsa
Clinical Hospital of St. Luke
Email: perepelitsa_vit@mail.ru
ORCID iD: 0000-0002-7656-4473
SPIN-code: 7445-1996
Scopus Author ID: 14823999900
Cand. Sci. (Med.), urologist
Russian Federation, Saint PetersburgNikolai S. Bunenkov
Clinical Hospital of St. Luke; Academician I.P. Pavlov First St. Petersburg State Medical University; Almazov National Medical Research Centre
Email: bunenkov2006@gmail.com
ORCID iD: 0000-0003-4331-028X
SPIN-code: 3611-1290
Cand. Sci. (Med.), surgeon
Russian Federation, Saint Petersburg; Saint Petersburg; Saint PetersburgAnna S. Ulitina
Clinical Hospital of St. Luke; Academician I.P. Pavlov First St. Petersburg State Medical University
Email: anna.s.ulitina@yandex.ru
ORCID iD: 0000-0003-3011-1812
SPIN-code: 3895-7799
Cand. Sci. (Med.)
Russian Federation, Saint Petersburg; Saint PetersburgReferences
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