Features of immunopathogenesis of atopic dermatitis


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Abstract

 Atopic dermatitis is one of the most common allergic diseases with severe course, which affects the skin. This disease is genetically determined and has a chronic course. Atopic dermatitis is also one of the commonest diseases (between 20% and 40% of all skin disorders) and affects patients of both sexes across the globe. Such high rate of morbidity, onset in early childhood, often continuous relapsing course and a trend toward gradual increase of tolerance to traditional therapies makes the issue of detalization of pathogenesis of atopic dermatitis particularly topical. Immune cells play one of the major roles in the pathogenesis of atopic dermatitis. This article will systematically review the main available to date information on participation immune cells in the pathogenesis of atopic dermatitis.

About the authors

Olga O. Pobezhimova

Samara State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: ImmunologSamara888@yandex.ru
ORCID iD: 0000-0001-9593-4807

graduate student of department of the general and clinical microbiology, allergology and immunology

Russian Federation, 18, Gagarina str., Samara, 443099

Alexsander V. Zhestkov

Samara State Medical University, Ministry of Health of Russia

Email: avzhestkov@yandex.ru
ORCID iD: 0000-0002-3960-830X

MD, PhD, Professor, Chief of Department of Microbiology, Immunology and Allergology

Russian Federation, 18, Gagarina str., Samara, 443099

Olga S. Sidorova

Samara State Medical University, Ministry of Health of Russia

Email: rambleruse@rambler.ru
ORCID iD: 0000-0002-9183-745X

Candidate of Medical Sciences, Associate Professor of the Department of the general and clinical microbiology, allergology and immunology

Russian Federation, 18, Gagarina str., Samara, 443099

Vera V. Kulagina

Private institution educational organization of higher education “Мedical University Reaviz”

Email: vvksam@mail.ru
ORCID iD: 0000-0002-8824-0046

MD, PhD, Associate Professor of the Department of Clinical Medicine

Russian Federation, 227, Chapayevskaya str., Samara, 443001

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