IgE-response to H. pylori in children with gastroduodenal diseases and allergy
- Authors: Ilintseva NV1, Mazurina SA1, Gervazieva VB1
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Affiliations:
- Mechnickov Research Institute for Vaccines and Sera, RAMS
- Issue: Vol 7, No 3 (2010)
- Pages: 24-29
- Section: Articles
- URL: https://journals.rcsi.science/raj/article/view/121377
- DOI: https://doi.org/10.36691/RJA885
- ID: 121377
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Abstract
Background. To evaluate the impact of atopic reactivity in humoral immune response to H. pylori in children with gastroduodenal diseases.
Materials and methods. In 69 children with gastroduodenal diseases and in 14 healthy people we revealed the total IgE level, IgM-, IgG-, IgA- and IgE-antibodies to H. pylori in serum samples, slgA in saliva and IgE- antibodies to H. pylori in supernatant samples of faeces with ELISA method.
Results. Chronic gastritis/gastroduodenitis in children with allergy are associated with a lower frequency of detection of IgG-and IgA- antibodies to H. pylori as well as with lower level of slgA and elevated levels of total IgE и IgE- antibodies to H. pylori in sera. Conversely, non-atopic patients showed high levels of slgA and high frequency of detection of IgA- antibodies to H. pylori. 60% of non-atopic children with gastroduodenal ulcers had elevated total IgE level, but IgE level to H. pylori was low as well as in healthy control group. IgE antibodies to H. pylori were detected in 95-100% of supernatant samples of faeces in all groups of patients with the highest level of IgE antibodies in children with gastroduodenal ulcers. It was revealed the direct correlation between the IgE antibodies to H. pylori level in serum and in supernatant samples of faeces in atopic children. Conclusion. The elevation of IgE antibodies to H. pylori is a result of constitutive Th2 immune response which reflects the mechanisms of mucosal immune defense independently from associated atopic diseases.
Materials and methods. In 69 children with gastroduodenal diseases and in 14 healthy people we revealed the total IgE level, IgM-, IgG-, IgA- and IgE-antibodies to H. pylori in serum samples, slgA in saliva and IgE- antibodies to H. pylori in supernatant samples of faeces with ELISA method.
Results. Chronic gastritis/gastroduodenitis in children with allergy are associated with a lower frequency of detection of IgG-and IgA- antibodies to H. pylori as well as with lower level of slgA and elevated levels of total IgE и IgE- antibodies to H. pylori in sera. Conversely, non-atopic patients showed high levels of slgA and high frequency of detection of IgA- antibodies to H. pylori. 60% of non-atopic children with gastroduodenal ulcers had elevated total IgE level, but IgE level to H. pylori was low as well as in healthy control group. IgE antibodies to H. pylori were detected in 95-100% of supernatant samples of faeces in all groups of patients with the highest level of IgE antibodies in children with gastroduodenal ulcers. It was revealed the direct correlation between the IgE antibodies to H. pylori level in serum and in supernatant samples of faeces in atopic children. Conclusion. The elevation of IgE antibodies to H. pylori is a result of constitutive Th2 immune response which reflects the mechanisms of mucosal immune defense independently from associated atopic diseases.
About the authors
N V Ilintseva
Mechnickov Research Institute for Vaccines and Sera, RAMS
Email: vbger@mail.ru
Mechnickov Research Institute for Vaccines and Sera, RAMS
S A Mazurina
Mechnickov Research Institute for Vaccines and Sera, RAMSMechnickov Research Institute for Vaccines and Sera, RAMS
V B Gervazieva
Mechnickov Research Institute for Vaccines and Sera, RAMSMechnickov Research Institute for Vaccines and Sera, RAMS
References
- Бельмер С.В., Гасилина Т.В., Аль Хатиб М. Helicobacter pylori и аллергия. Леч. врач. 2004, № 4, с. 56-58.
- Карельская И.А, Игнатьев В.К. Инфекция Helicobacter pylori у больных с хронической крапивницей и бронхиальной астмой. Клин, медицина. 2005, № 3, с. 58-61.
- Соколова ТВ. Влияние на течение атопического дерматита у взрослых инфекции Helicobacter pylori и схемы ее эрадикации. Consilium Medicum (Приложение). 2004, № 1, с. 3-6.
- Калимолдаева С.Б. Хроническая крапивница: этиопатогенетическая роль инфекции Helicobacter pylori и разработка методов лечебно-профилактической коррекции. Автореферат диссертации д-ра мед. наук. Алма-аты. 2008, 50 с.
- Чамсутдинов Н.У. Морфофункциональная оценка состояния ЖКТ у больных бронхиальной астмой. Вестник СПб государственной медицинской академии им. И.И. Мечникова. 2004, № 4, с. 162-166.
- Хаитов P.M., Игнатьева Г.А., Сидорович И.Г. Иммунология. М., «Медицина». 2000.
- Mayer L. Mucosal Immunity. Pediatrics. 2003, III, p. 1595-1600.
- Шкитин В.А., Шпирна А.И., Старовойтов Г.Н. Роль Helicobacter pylori в патологии человека. Клин, микробиол. и химиотер. 2002, т. 4, № 2, с. 128-145.
- Munoz- Lopez F. Helicobacter pylori and Allergic Disease. Allergol Immunopathol (Madr). 2003, v. 31, p. 253-255.
- John C. Atherton, Martin J. Blaser. Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. J. Clin. Invest. 2009, v. 119 (9), p. 2475-2487.
- Чернуцкая СП., Гервазиева В.Б., Сухарева Г.В. Роль Н. pylori в развитии аллергических заболеваний. Экспер. клин. гастроэнтерология. 2008, № 4, с. 17-20.
- De Lazzari E, Mancin О., Plebani M. et al. High IgE serum levels and «peptic» ulcers: clinical and functional approach. Ital. J. Gastroenterol. 1994, v. 26 (1), p. 7-11.
- Канарейцева Е.Д., Чернуцкая С.П., Еервазиева В.Б., Сухарева ЕВ. Морфоиммунологические критерии диагностики гастрита, ассоциированного с Helicobacter pylori. Экспер. клин, гастроэнтерология. 2010, № 2, с. 22-26.
- Berczi L., Sebestyen A., Fekete В. et al. IgE-containing cells in gastric mucosa with and without Helicobacter pylori infection. Pathol. Res. Pract. 2000, v. 196 (12), p. 831-834.
- Liutu M., Kalimo K., Kalimo H. et al. Mast cells and IgE-containing cells in gastric mucosa of Helicobacter pylori infected and non-infected patients with chronic urticaria. J. Eur. Acad. Dermatol. Venerol. 2004, v. 18, p. 69-72.
