Detection of IgE-antibodies to recombinant birch allergens rBet v 1 and rBet v 2 in patients withsensitization to birch pollen
- Authors: Mokronosova MA1, Sergeev AV1, Korovkina ES1, Konyukova NG2, Mokronosova MA3, Sergeev AV3, Korovkina ES3, Konjucova NG4
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Affiliations:
- Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН
- Фгу «Московский научно-исследовательский институт педиатрии и детской хирургииРосмедтехнологий»
- I. Mechnikov Research Institute for Vaccines and Sera, RAMS
- Moscow Research Institute of Pediatric and Child Surgery
- Issue: Vol 8, No 4 (2011)
- Pages: 45-48
- Section: Articles
- URL: https://journals.rcsi.science/raj/article/view/121173
- DOI: https://doi.org/10.36691/RJA847
- ID: 121173
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Abstract
and specific IgE determination. the past decade recombinant allergen components from pollen of birch are
available for allergen-specific IgE antibody testing. the major allergen of birch tree pollen is Bet v 1; Bet v 2 is a
well described minor allergen.
Methods. 83 patients with birch pollinosis (55 male/28 female, age 4-35 years, mean 15,5) were observed. specific
IgE levels were determined by using the ImmunoCap (Phadia, sweden); skin prick tests with standard aeroallergens
panel was used.
Results. All 83 patients had positive skin tests to birch pollen. the levels of specific IgE to rBet v1 had 87,9% of
patients, sIgE to rBet v 2 (profilin) 14,5% of patients, sIgE to rBet v 1 and rBet v 2 13,3% of patients.
Conclusion. the prevalence of the patients with presence of IgE - antibodies to profiling Bet v2 among citizens
of moscow region, sensitized to birch, accounts 14,5%.
Keywords
About the authors
M A Mokronosova
Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН
Email: mmokronosova@mail.ru
Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН
A V Sergeev
Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМННаучно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН
E S Korovkina
Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМННаучно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН
N G Konyukova
Фгу «Московский научно-исследовательский институт педиатрии и детской хирургииРосмедтехнологий»Фгу «Московский научно-исследовательский институт педиатрии и детской хирургииРосмедтехнологий»
M A Mokronosova
I. Mechnikov Research Institute for Vaccines and Sera, RAMSI. Mechnikov Research Institute for Vaccines and Sera, RAMS
A V Sergeev
I. Mechnikov Research Institute for Vaccines and Sera, RAMSI. Mechnikov Research Institute for Vaccines and Sera, RAMS
E S Korovkina
I. Mechnikov Research Institute for Vaccines and Sera, RAMSI. Mechnikov Research Institute for Vaccines and Sera, RAMS
N G Konjucova
Moscow Research Institute of Pediatric and Child SurgeryMoscow Research Institute of Pediatric and Child Surgery
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