THE INFLUENCE OF TOPICAL GLUCOCORTICOSTEROIDS ONCYTOKINE GENE EXPRESSION IN THE SKIN AND PERIPHERALBLOOD OF ATOPIC DERMATITIS PATIENTS
- Authors: Filimonova T.M.1, Elisyutina OG1, Fedenko ES1, Burmenskaya OV2, Boldyreva MN1, Filimonova TM3, Elisyutina OG3, Fedenko ES3, Burmenskaya OV4, Boldyreva MN3
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Affiliations:
- ФГБУ «ГНЦ Институт иммунологии» ФМБА России
- ФГУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова»Минздравсоцразвития России
- Institute of Immunology
- Scientific Center for Obstetrics, gynecology and perinatology named after V.I. kulakov
- Issue: Vol 8, No 3 (2011)
- Pages: 19-30
- Section: Articles
- URL: https://journals.rcsi.science/raj/article/view/121131
- DOI: https://doi.org/10.36691/RJA779
- ID: 121131
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Abstract
skin and peripheral blood of atopic dermatitis (AD) patients comparing with control.
Material and methods. 40 AD patients were included in the study and divided into 2 groups. group 1 patients
were given continuous course of mometasone furoate 0,1% cream treatment for 14 days. group 2 patients were
given indifferent emollient elobase cream for 14 days. Clinical efficacy of the treatment was assessed on the
following features: SCORAD index, Investigators global Assessment (IgA) score and subjective assessment of
itch and dryness of the skin according to skin area to be studied. Skin samples and peripheral blood of atopic
dermatitis were used as material for immunological study. Interleukin (IL)1B, IL2, IL2r, IL4, IL5, IL6, IL7, IL8, IL10,
IL 12A, IL12B, IL15 (total), IL15 , IL17A, IL18, IL23, IL28, IL29, Interferon (IFN)-, Tumor necrosis factor (TNF),
Transforming growth factor beta 1 (TGFB1), forkhead box P3 (FOXP3) gene expression were defined in the skin
and peripheral blood of AD patients by realtime reverse transcription polymerase chain reaction (RT-pCR).
Results. positive clinical effect was found with all AD patients on the mometasone furoate 0,1% cream therapy
background for 14 days and also dryness, rushes and skin itch decreased. Stаtistical significant decrease of proinflammatory
cytokines IL2, IL2r, IL5, IL8, IL12В, IL23, IFN- gene expression was marked. They are the markers
of chronic inflammation and Th1 immune response. Studying peripheral blood after mometasone furoate 0,1%
cream treatment increase of TGFB1, FOXP3 gene expression level was found. no significant changes of cytokine
gene expression in AD patients, who got elobase cream were found.
Conclusion. Antiinflammatory activity of mometasone furoate 0,1% cream was shown by its influence on proinflammatory
cytokines IL2, IL2r, IL5, IL8, IL12В, IL23, IFN- gene expression in the skin and mechanisms of
immune response in moderate and severe AD patients.
About the authors
Tat'yana Mikhaylovna Filimonova
ФГБУ «ГНЦ Институт иммунологии» ФМБА России
Email: tatfil-doc@yandex.ru
ФГБУ «ГНЦ Институт иммунологии» ФМБА России
O G Elisyutina
ФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииФГБУ «ГНЦ Институт иммунологии» ФМБА России
E S Fedenko
ФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииФГБУ «ГНЦ Институт иммунологии» ФМБА России
O V Burmenskaya
ФГУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова»Минздравсоцразвития РоссииФГУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова»Минздравсоцразвития России
M N Boldyreva
ФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииФГБУ «ГНЦ Институт иммунологии» ФМБА России
T M Filimonova
Institute of ImmunologyInstitute of Immunology
O G Elisyutina
Institute of ImmunologyInstitute of Immunology
E S Fedenko
Institute of ImmunologyInstitute of Immunology
O V Burmenskaya
Scientific Center for Obstetrics, gynecology and perinatology named after V.I. kulakovScientific Center for Obstetrics, gynecology and perinatology named after V.I. kulakov
M N Boldyreva
Institute of ImmunologyInstitute of Immunology
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