Experimental modeling of behavioral disorders accompanying hashimoto’s thyroiditis by means of specific immunoglobulins
- Authors: Sobolevskaia P.A.1, Gvozdeckii A.N.2, Utekhin V.J.1,3, Efimova E.V.1, Kuvarzin S.R.1, Fedotkina T.V.1,3, Churilov L.P.1,4
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Affiliations:
- Saint Petersburg State University
- I.I. Mechnikov North-Western State Medical University, Ministry of Healthcare of the Russian Federation
- Saint Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
- Saint Petersburg Scientific Research Institute of Phthisiopulmonology
- Issue: Vol 12, No 3 (2021)
- Pages: 31-41
- Section: Original studies
- URL: https://journals.rcsi.science/pediatr/article/view/83053
- DOI: https://doi.org/10.17816/PED12331-41
- ID: 83053
Cite item
Abstract
Among the manifestations of Hashimoto’s autoimmune thyroiditis, there are various psychoneurological disorders. For more than a century, it has been known about psycho-neurological disorders associated with hypothyroidism, but along with that, there are also mental disorders in patients with thyropathies in euthyroid state. In 1966, Hashimoto’s encephalopathy was described, the pathogenesis and clear differential diagnostic criteria of which have not yet been determined. This article describes an experimental study in laboratory mice with intracisternal stereotaxic injection of IgG isolated from patients with autoimmune thyroiditis and comorbid depression or schizophrenia. A control group included animals receiving polyclonal IgG from healthy donors. Then behavioral tests were carried out, which revealed the characteristics and changes in behavior in the operated animals. Thus, animals that received immunoglobulins from patients with autoimmune thyroiditis and depression were less active in relation to the development of risk behavior. Porsolt’s tests on the 4th and 15th days after surgery showed that, regardless of the kind of the injected solutions, there was a change in the temporal relationships between the behavior patterns. In mice received IgG from patients with autoimmune thyroiditis and schizophrenia during the delayed Porsolt test, the ratio of the forms of motor activity shifted towards passive swimming. The mice received IgG from healthy donors did not demonstrate this change.
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##article.viewOnOriginalSite##About the authors
Polina A. Sobolevskaia
Saint Petersburg State University
Author for correspondence.
Email: dr.polinasobolevskaia@bk.ru
Researcher
Russian Federation, Saint PetersburgAnton N. Gvozdeckii
I.I. Mechnikov North-Western State Medical University, Ministry of Healthcare of the Russian Federation
Email: comisora@yandex.ru
Assistant Professor, Department of Psychiatry and Narcology
Russian Federation, Saint PetersburgVladimir J. Utekhin
Saint Petersburg State University; Saint Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: utekhin44@mail.ru
MD, PhD, Associate Professor, Department of Pathologic Hpysiology Pcourses Immunopathology and Medical Informatics
Russian Federation, Saint Petersburg; Saint PetersburgEvgenia V. Efimova
Saint Petersburg State University
Email: e.v.efimova@mail.ru
PhD, Senior Researcher
Russian Federation, Saint PetersburgSavelii R. Kuvarzin
Saint Petersburg State University
Email: saveliy51@yandex.ru
младший научный сотрудник
Russian Federation, Saint PetersburgTamara V. Fedotkina
Saint Petersburg State University; Saint Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: t.v.fedotkina@gmail.com
PhD, Associate Professor, Department of Histology and Embryology
Russian Federation, Saint Petersburg; Saint PetersburgLeonid P. Churilov
Saint Petersburg State University; Saint Petersburg Scientific Research Institute of Phthisiopulmonology
Email: elpach@mail.ru
MD, PhD
Russian Federation, Saint Petersburg; Saint PetersburgReferences
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