Effective of antiviral therapy of HIV infection and intercurrent diseases in children

Cover Page

Cite item

Full Text

Abstract

The study included 366 HIV-infected children (under-23) and 350 children with perinatal contact with HIV infection (R-75), consisting on the dispensary account in the Department of motherhood and childhood of the Saint Petersburg city AIDS center. The vast majority of children with perinatal HIV receive HAART (95.0%) with high efficacy (undetectable viral load, normalization of CD4 lymphocytes, the absence of clinical manifestations). In the structure of opportunistic viral infections (herpes, respiratory infections) 40.0%, bacterial (bronchitis, tonsillitis, pyoderma, pulmonary tuberculosis) - 28.6%, fungal infections (candidiasis mucous membranes of the oral cavity) and Pneumocystis pneumonia - 31.4%. Complex therapy (etiotropic, pathogenetic, symptomatic) acute respiratory viral infections in children with B-23 and R-75, allows us to achieve in the early stages (6 days treatment) of the regression of the main symptoms of acute respiratory diseases.

About the authors

Vladimir N Timchenko

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: timchenko220853@yandex.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of Infectious Diseases in Children in the name of M. G. Danilevich Russian Federation

Elena B Yastrebova

I.P. Pavlov First St Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation

Email: elena_yastrebova@inbox.ru
MD, PhD, Dr Med Sci, Associate Professor. Russian Federation

Oksana V Bulina

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Email: detinfection@mail.ru
MD, PhD, Associate Professor. Russian Federation

References

  1. Национальные клинические рекомендации по диагностике и лечению ВИЧ-инфекции у детей и подростков / Национальная ассоциация вирусологов. — М., 2013. — 16 с. [National clinical guidelines for the diagnosis and treatment of HIV infection in children and adolescents. National Association of Virology. Moscow; 2013. P. 16. (In Russ.)]
  2. Тимченко В.Н., Архипова Ю.А., Булина О.В. Опыт лечения хронического вирусного гепатита С у детей, рожденных ВИЧ-позитивными женщинами // Детские инфекции. — 2015. — Т. 14. — № 4. — С. 45–49. [Timchenko VN, Arkhipov AYu, Bulina OV. Experience in the treatment of chronic viral hepatitis C in children born to HIV-positive women. Children’s infections. 2015;14(4):45-49. (In Russ.)]
  3. Тимченко В.Н., Архипова Ю.А., Джангавидзе Н.Д. Клинико-эпидемиологические особенности ВИЧ-инфекции у детей первого года жизни // ВИЧ-инфекция и иммуносупрессии. — 2012. — Т. 4. — № 4. — С. 80–87. [Timchenko VN, Arkhipova YuA, Dgangavadze ND. The clinical-epidemiological features of HIV-infectionfor the children of first-year of life. HIV-infection and Immunosuppressions. 2012;4(4):80-87. (In Russ.)]
  4. Тимченко В.Н., Архипова Ю.А., и др. Особенности физического развития детей первого года жизни, рожденных ВИЧ-позитивными женщинами // Педиатр. — 2010. — Т. 1. — № 2. — С. 97–101. [Timchenko VN, Arkhipova YuA. The features of physical development of first-year infants born to HIV-positive women. Pediatr. 2010;1(2):97-101. (In Russ.)]
  5. Ястребова Е.Б., Рахманова А.Г., Курильская М.Б., и др. Перинатальная ВИЧ-инфекция у детей Санкт-Петербурга (клиника, диагностика, лечение) // Эпидемиология и инфекционные болезни. — 2006. — № 6. — С. 27–31. [Yastrebova EB, Rakhmanova AG, Kurilskaya MB, et al. Perinatal HIV-infection for the children of Saint Petersburg (clinic, diagnostics, treatment). Epidemiology and Infectious Diseases. 2006;(6):27-31. (In Russ.)]
  6. Ястребова Е.Б., Рахманова А.Г., Щербук Ю.А. Пути передачи ВИЧ как факторы риска прогрессирования заболевания у детей // Детские инфекции. — 2011. — Т. 10. — № 4. — С. 14–17. [Yastrebova EB, Rakhmanova AG, Shcherbuk YuA. Ways of transmission of HIV as risk of progress of disease factors for children. Detskie infekcii. 2011;10(4)14-17. (In Russ.)]
  7. Ястребова Е.Б., Самарина А.В. Анализ клинико-эпидемиологических характеристик ВИЧ-инфицированных детей в Санкт-Петербурге // ВИЧ-инфекция и иммуносупрессии. — 2014. — Т. 6. — № 2. — С. 74–79. [Yastrebova EB, Samarina AV. Analysis of clinical-epidemiological descriptions of the HIV-infected children in Saint Petersburg. HIV-infection and Immunosupressions. 2014;6(2)74-79. (In Russ.)]

Copyright (c) 2017 Timchenko V.N., Yastrebova E.B., Bulina O.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies