Clinical and laboratory peculiarities of combined clinical course of metabolic and articular syndromes

Aim. To identify clinical and laboratory peculiarities of a combined clinical course of metabolic and articular syndromes.

Materials and Methods. In the research 126 individuals participated. They were arranged into 3 groups: the 1^st group included 46 patients with comorbid pathology, the 2^nd group – 44 patients with metabolic syndrome, and the 3^d group – 36 patients with articular syndrome. The following parameters were evaluated: anthropometric data (height, body mass, body mass index, waist circumference), lipid spectrum, glycohemoglobin, nonspecific markers of inflammation, daily profile of arterial pressure.

Results. In the group with comorbid pathology higher average values of body mass were recorded – 115.8 [60;140] kg in comparison with the 2^nd and 3^d groups – 93.5 [72;130] and 71.5 [58;98] kg, respectively; erythrocyte sedimentation rate – 18.3 [5;34] mm/h was reliably higher than in the 2^nd group (11.5 [2;24] mm/h), and median cholesterol (6.18 [5,39;6,85] mmol/L) was higher than in the 3^d group (4.82 [3,48;5,61] mmol/L). In the 1^st and 2^nd groups higher average values of systolic arterial pressure were recorded in comparison with the 3^d group – 158,5 [120;190]; 154,6 [115;190] and 126,4 [96;168] mm Hg, respectively.

Conclusions. In patients with combined metabolic and articular syndromes higher values of body mass and systolic arterial pressure were identified. Based on the laboratory findings, parameters of cholesterol and erythrocyte sedimentation rate were higher in patients with comorbid condition than in those with the isolated pathologies.