Role of Microribonucleic acid in the Carcinogenesis of Non-Small-Cell Lung Cancer

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Abstract

INTRODUCTION: Lung cancer is the most common malignant neoplasm. Despite advances in target therapy, immunotherapy, and chemotherapy, non-small cell lung cancer remains the major cause of cancer-related death worldwide. Tumor development is a complex process that depends on the influence of environmental factors and genetic predisposition. Although oncogenic factors have received much attention, the main mechanisms for oncogenesis are still poorly understood. Thus, studying the oncogenic mechanisms, including those with the involvement of microribonucleic acid (microRNA), is important for the diagnostics and treatment of malignant neoplasms. MicroRNA (miRNA) belong to the class of small non-coding ribonucleic acids that are involved in various cellular biological processes, including epithelial–mesenchymal transition, apoptosis, proliferation, invasion, and metastatic dissemination of cancer cells. Recent publications show that the course of the oncological disease can be predicted by evaluating the expressions of some miRNAs. Therefore, miRNAs serve as promising diagnostic and therapeutic targets in oncological diseases.

CONCLUSION: This review summarizes data on the role in carcinogenesis and prognostic significance of several miRNA (i.e., miRNA-128, -4500, -222, -224, -124, -125b, -127, -129-2, -137, and -375) in non-small cell lung cancer.

About the authors

Marina S. Gubenko

Institute of General Pathology and Pathophysiology

Email: artz_marina@mail.ru
ORCID iD: 0000-0001-5439-9713
SPIN-code: 4992-7397
Russian Federation, Moscow

Vitaliy I. Loginov

Institute of General Pathology and Pathophysiology

Email: werwolf2000@mail.ru
ORCID iD: 0000-0003-2668-8096
SPIN-code: 6249-5883

Cand. Sci. (Biol.)

Russian Federation, Moscow

Aleksey M. Burdennyy

Institute of General Pathology and Pathophysiology

Email: koldun.pro@mail.ru
ORCID iD: 0000-0002-9398-8075
SPIN-code: 4429-4288

Cand. Sci. (Biol.)

Russian Federation, Moscow

Irina V. Pronina

Institute of General Pathology and Pathophysiology

Email: p.lenyxa@yandex.ru
ORCID iD: 0000-0002-0423-7801
SPIN-code: 5706-2369

Cand. Sci. (Biol.)

Russian Federation, Moscow

Svetlana V. Khokhlova

National Medical Research Center of Obstetrics, Gynecology and Perinatology named after academician V. I. Kulakov

Email: svkhokhlova@mail.ru
ORCID iD: 0000-0002-4121-7228
SPIN-code: 6009-4616

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Sergey S. Pertsov

P. K. Anokhin Research Institute of Normal Physiology

Author for correspondence.
Email: s.pertsov@mail.ru
ORCID iD: 0000-0001-5530-4990
SPIN-code: 3876-0513

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

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