Variability of heart rhythm in patients with myocardial infarction with Q wave with standard therapy and nutritive support with organic selenium

Aim. Assessment if the interrelation of the levels of selenium, parameters of heart rate variability (HRV), biochemical and rheological characteristics of blood in patients with Q-myocardial infarction (Q-MI) taking standard medicinal therapy and dietary correction with organic selenium in different stages of the disease.

Materials and Methods. An open comparative clinical study was conducted with involvement of 90 patients (the average age 58.3±1.4, of them 71 men and 19 women) diagnosed with acute coronary syndrome with elevation of Q-segment with outcome into Q-MI. The patients were divided to two comparable groups: control group that received standard therapy, and the main group that additionally received dietary product enriched with organic selenium. In acute, subacute and cicatrization stages, the dynamic series of RR intervals were recorded and mathematically analyzed on Varicard 2.51 complex, some biochemical parameters of blood, selenium status, rheological properties of blood were assessed.

Results. In the stage of hospital treatment, reduction of the heart rate (from 68.8±1.7 to 64.0±1.3 beat/min; p<0.05) was recorded in the main group. The initial level of SDNN in both groups was within the critical range (25.0±1.3 msec), and stress index (SI) several time exceeded the norm (1356.2±390.6 conv.un.); by the end of the observation both parameters did not achieve normal values in both groups. The coefficient of variation (CV) stayed below normal values throughout the whole treatment period, although in the dynamics it showed some tendency to growth. The spectrum power of the curve enveloping the dynamic series of RR intervals (HF) almost twice increased in the control group (р<0.05). Correlation analysis of the interrelation of biochemical parameters of blood, coagulogram and selenium of blood serum with different parameters of mathematical analysis of the heart rhythm revealed interrelations of different levels and direction.

Conclusion. Use of dietary product rich in selenium having a positive effect on the trophotropic functions of an organism, in complex with standard therapy, reduces tension of adaptation mechanisms and enhances adaptation potential of an organism that improves the prognosis and reduces risks.