标准疗法及有机硒营养支持治疗Q-心肌梗塞患者的心率变异性

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目的：在使用有机硒进行标准药物治疗和膳食校正的背景下，评价Q-心肌梗塞患者不同病程时期、心率变异性指标、血液生化及流变学特征的关系。

材料与方法：对90例诊断为急性冠状动脉综合征、节段抬高、结果为Q-心肌梗死的患者（平均年龄为58.3±1.4岁，其中男生71例，女生19例）进行了开放的比较临床研究。患者被分成两组：对照组接受标准治疗，主要的治疗—另外，一种富含有机硒的饮食产品。在Q型心肌梗死的急性期、亚急性期和瘢痕期，采用Varicard 2.51复合材料对动态心脏间隔进行登记和数学分析，并对血液生化指标、硒状态和血液流变学特性进行评价。

结果：在住院治疗阶段，主组患者的心率下降（从68.8±1.7次降至64.0±1.3次/分；p < 0.05）。一开始，两组的SDNN水平均在临界值（25.0±1.3毫秒）内，压力指数（SI）比正常值高出数倍（1356.2±390.6标准单位），观察结束时，两组均未达到正常值。在整个治疗过程中，两组的变异系数（CV）均低于正常值，但动态上有轻微上升趋势。对照组心脏隔动态范围（HF）曲线谱的功率增加近2倍（p <0.05）。通过对血液生化指标、血清凝血和硒水平与心律数学分析的各个参数的相关性分析，发现它们在水平和方向上存在着不同的联系。

结论。使用富含硒的膳食产品，积极影响机体的滋养功能，结合标准疗法，可降低适应机制的张力，增加机体的适应潜力，有助于改善预后，降低风险。

作者简介

Elena Radchenko

Ryazan State Medical University

编辑信件的主要联系方式.
Email: lenusik.25@mail.ru
ORCID iD: 0000-0001-5097-424X
SPIN 代码: 3833-5180

Assistant of the Internal Diseases Department

俄罗斯联邦, Ryazan

Aleksej Nizov

Ryazan State Medical University

Email: lenusik.25@mail.ru
ORCID iD: 0000-0001-7531-9102
SPIN 代码: 2939-8193
Researcher ID: M-7081-2018

MD, PhD, Professor, Head of the Department of Internal Diseases

俄罗斯联邦, Ryazan

Mikhail Lapkin

Ryazan State Medical University

Email: lenusik.25@mail.ru
ORCID iD: 0000-0003-1826-8307
SPIN 代码: 5744-5369
Researcher ID: S-2722-2016

MD, PhD, Professor, Head of the Department of Normal Physiology with Course in Psychophysiology

俄罗斯联邦, Ryazan

Vladimir Yudin

Ryazan State Medical University

Email: lenusik.25@mail.ru
ORCID iD: 0000-0001-6385-7413
SPIN 代码: 1463-2810
Researcher ID: B-6212-2018

MD, PhD, Professor, Professor of the Department of Surgery

俄罗斯联邦, Ryazan

Roman Zorin

Ryazan State Medical University

Email: lenusik.25@mail.ru
ORCID iD: 0000-0003-4310-8786
SPIN 代码: 5210-5747
Researcher ID: G-8833-2018

MD, PhD, Associate Professor, Associate Professor of the Department of Neurology and Neurosurgery

俄罗斯联邦, Ryazan

Sergey Aksentiev

Regional Clinical Hospital

Email: lenusik.25@mail.ru
ORCID iD: 0000-0002-0507-520X
SPIN 代码: 8953-6225
Researcher ID: V-2811-2018

MD, PhD, Head of the Department of Emergency Cardiology

 
俄罗斯联邦, Ryazan

Vladimir Mazo

Scientific Research Institute of Nutrition

Email: lenusik.25@mail.ru
ORCID iD: 0000-0003-2163-091X
SPIN 代码: 4142-4720
Researcher ID: P-5668-2018

Doctor of Biological Sciences, Prof., Leading Researcher, Laboratory of Food Biotechnologies and Specialized Products

俄罗斯联邦, Moscow

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版权所有 © Radchenko E., Nizov A., Lapkin M., Yudin V., Zorin R., Aksentiev S., Mazo V., 2020

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