Neurotrophic keratopathy and Wallenberg – Zakharchenko syndrome: a clinical case

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BACKGROUND: Degenerative changes of cornea after transection of the trigeminal nerve were first described by F. Magendie in 1824. Neurotrophic keratopathy is considered to be an orphan disease which lately has been recognized more and more often. According to literature data, neurotropchic keratopathy affects 5 individuals in 10,000. The diagnosis is difficult due to the lack of information about this condition, the rare occurrence and the presence of a large number of etiological factors.

AIM: To determine the causes of the neurotrophic keratopathy development and the treatment tactics in a patient with a neurological disease. The article presents a case of neurotrophic keratopathy in a patient with Wallenberg – Zakharchenko syndrome.

Because of the fact that neurotrophic keratopathy was diagnosed late and the correct treatment did not start in time, further progression of the pathological process in the cornea could not be avoided. Periodic recurrence of neurotrophic keratopathy is associated with an underlying chronic neurological disease.

CONCLUSIONS: Neurotrophic keratopathy requires early diagnosis. In certain clinical cases, for the successful treatment of this pathology, it is necessary to prescribe systemic therapy.

作者简介

Maggie Ezugbaya

Academician I.P. Pavlov First St. Petersburg State Medical University

编辑信件的主要联系方式.
Email: maggie-92@mail.ru
ORCID iD: 0000-0002-0421-1804

МD,Postgraduate Research student, Ophthalmology Department

俄罗斯联邦, 6–8, L’va Tolstogo str., Saint Petersburg, 197022

Sergey Astakhov

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: astakhov73@mail.ru
ORCID iD: 0000-0003-0777-4861
SPIN 代码: 7732-1150

МD,PhD, DMedSc, Professor, head of the department, Ophthalmology Department

俄罗斯联邦, 6–8, L’va Tolstogo str., Saint Petersburg, 197022

Inna Riks

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: riks0503@yandex.ru
ORCID iD: 0000-0002-5187-1047
SPIN 代码: 4297-6543

МD, PhD, Assistant, Ophthalmology Department

俄罗斯联邦, 6–8, L’va Tolstogo str., Saint Petersburg, 197022

Sanasar Papanyan

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: Dr.papanyan@yandex.ru
ORCID iD: 0000-0003-3766-2211
SPIN 代码: 9794-4692

МD, PhD, Ophtalmologist, Ophthalmology Department

俄罗斯联邦, 6–8, L’va Tolstogo str., Saint Petersburg, 197022

Rafik Boutaba

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: boutabarafik@yahoo.fr
ORCID iD: 0000-0002-3700-8255

МD, Clinical Resident, Ophthalmology Department

俄罗斯联邦, 6–8, L’va Tolstogo str., Saint Petersburg, 197022

Yuliya Mikhalchenko

Clinic “Scandinavia”, LLC “AVA-PETER”

Email: erisod29@mail.ru

ophthalmologist

俄罗斯联邦, Saint Petersburg

Alexey Yakushenko

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: yakushenkoalex@yandex.ru

student

俄罗斯联邦, 6–8, L’va Tolstogo str., Saint Petersburg, 197022

参考

  1. Magendie F. The influence of the fifth pair of nerves on nutrition and function of the eye. J Physiol Exp Pathol. 1824;4:176–182. (In French.)
  2. Dua HS, Said DG, Messmer EM, et al. Neuropathic Keratopathy. [Internet] Progress in Retinal and Eye Research, 2018. Available from: https://research.birmingham.ac.uk/portal/en/publications/neurotrophic-keratopathy(2478a374-6546-4972-a335-54590310c27c).html. doi: 10.1016/j.preteyeres.2018.04.003
  3. Bonini S, Rama P, Olzi D, Lambiase A. Neurotrophic keratitis. Eye (Lond). 2003;17:989–995. doi: 10.1038/sj.eye.6700616
  4. Morishige N, Morita Y, Yamada N, et al. Congenital hypoplastic trigeminal nerve revealed by manifestation of corneal disorders likely caused by neural factor deficiency. Case reports in ophthalmology. 2014;5(2):181–185. doi: 10.1159/000364899
  5. Lin X, Xu B, Sun Y, et al. Comparison of deep anterior lamellar keratoplasty and penetrating keratoplasty with respect to postoperative corneal sensitivity and tear film function. Graefe’s archive for clinical and experimental ophthalmology. 2014;252:1779–1787. doi: 10.1007/s00417-014-2748-6
  6. Wilson SE, Ambrosio R. Laser in situ keratomileusis-induced neurotrophic epitheliopathy. Am J Ophthalmol. 2001;132(3):405–406. doi: 10.1016/s0002-9394(01)00995-3
  7. Wilson SE, Ambrosio R. Laser in situ keratomileusis-induced neurotrophic epitheliopathy. Am J Ophthalmol. 2001;132(3):405–406. doi: 10.1016/s0002-9394(01)00995-3
  8. Lockwood A, Hope-Ross M, Chell P. Neurotrophic keratopathy and diabetes mellitus. Eye (Lond). 2006;20:837–839. doi: 10.1038/sj.eye.6702053
  9. Semeraro F, Forbice E, Romano V, et al. Neurotrophic keratitis. Ophthalmologica. 2014;231:191–197. doi: 10.1159/000354380
  10. Hsu HY, Modi D. Etiologies, Quantitative Hypoesthesia, and Clinical Outcomes of Neurotrophic Keratopathy. Eye Contact Lens. 2015;41(5):314–317. doi: 10.1097/ICL.0000000000000133
  11. Mackie IA. Neuroparalytic keratitis. In: Fraunfelder FT, Roy FH, Grove J, editors. Current Ocular Therapy, 4 ed. WB Saunders. Philadelphia, 1995. P. 452–454.
  12. Riks IA, Papanyan SS, Astakhov SYu, Novikov SA. Novel clinico-morphological classification of the corneal endothelial-epithelial dystrophy. Ophthalmology journal. 2017;10(3):46–52. (In Russ.) doi: 10.17816/OV10346-52
  13. Astakhov SYu, Novikov SA, Papanyan SS, Riks IA. Еvaluate the Effectiveness of Accelerated Collagen Crosslinking in the Treatment of Corneal Endothelial Decompensation. Ophthalmology in Russia. 2020;17(4): 699–704. (In Russ.) doi: 10.18008/1816-5095-2020-4-699-704
  14. Mastropasqua L, Nubile M, Lanzini M, et al. In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy. J Cell Physiol. 2019;234(5):6108–6115. doi: 10.1002/jcp.27345
  15. Kugadas A, Gadjeva M. Impact of Microbiome on Ocular Health. Ocul Surf. 2016;14(3):342–349. doi: 10.1016/j.jtos.2016.04.004
  16. Ayaki M, Iwasawa A, Niwano Y. In vitro assessment of the cytotoxicity of six topical antibiotics to four cultured ocular surface cell lines. Biocontrol Sci. 2012;17(2):93–99. doi: 10.4265/bio.17.93
  17. Bonini S, Lambiase A, Rama P, et al. Topical treatment with nerve growth factor for neurotrophic keratitis. Ophthalmology. 2000;107(7):1347–1351. doi: 10.1016/s0161-6420(00)00163-9
  18. Yamada N, Matsuda R, Morishige N, et al. Open clinical study of eye-drops containing tetrapeptides derived from substance P and insulin-like growth factor-1 for treatment of persistent corneal epithelial defects associated with neurotrophic keratopathy. Br J Ophthalmol. 2008;92(7):896–900. doi: 10.1136/bjo.2007.130013
  19. Guerra M, Marques S, Gil JQ, et al. Neurotrophic Keratopathy: Therapeutic Approach Using a Novel Matrix Regenerating Agent. J Ocul Pharmacol Ther. 2017;33(9):662–669. doi: 10.1089/jop.2017.0010
  20. Trufanov SV. Cyanoacrylate adhesive in surgical treatment of corneal perforation (clinical case). The Russian annals of ophthalmology. 2020;136(5–2):232–236. (In Russ.) doi: 10.17116/oftalma2020136052232

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2. Fig. 1. Clinical case of neurotrophic keratopathy. Biomicroscopy of the left eye: epithelial irregularity, dot-like epithelial defects within the optical zone

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3. Fig. 2. Optical coherence tomogram of the left cornea (explanation in the text). Examined by ophthalmologist S.G. Belekhova

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4. Fig. 3. In vivo confocal microscopy: a – desquamated epithelial cells; b – subbasal plexus (arrow); c – changes in the corneal stroma (explanation in the text)

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5. Fig. 4. Biomicroscopy of the cornea: extensive persistent epithelial defect in the optical and paraoptic zones

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6. Fig. 5. Corneal biomicroscopy. Fluorescein staining

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版权所有 © Ezugbaya M., Astakhov S., Riks I., Papanyan S., Boutaba R., Mikhalchenko Y., Yakushenko A., 2021

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