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发表评论 Personalized analysis of foveal avascular zone with optical coherence tomography angiography
- 作者: Burnasheva M.1, Kulikov A.1, Maltsev D.1
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隶属关系:
- S.M. Kirov Military Medical Academy
- 期: 卷 10, 编号 4 (2017)
- 页面: 32-40
- 栏目: Articles
- URL: https://journals.rcsi.science/ov/article/view/7786
- DOI: https://doi.org/10.17816/OV10432-40
- ID: 7786
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详细
Aim. To investigate the relationship between the foveal avascular zone (FAZ) and inner nuclear layer (INL) – free zone in order to provide a personalized approach for evaluation of the FAZ area with optical coherence tomography-angiography (OCTA).
Material and methods.Thirty-six healthy individuals (36 eyes) and 9 patients (12 eyes) with nonproliferative diabetic retinopathy (nPDR) were included in this study. The FAZ area as well as INL-free zone were measured in superficial capillary plexus on OCTA images. The FAZ area, INL-free area, and the ratio of the INL-free area to the FAZ area were compared between healthy subjects and nPDR patients.
Results. The mean FAZ area in healthy subjects and nPDR patients was 0.33 ± 0.1 and 0.56 ± 0.28 mm2 (p < 0.05), respectively. The mean INL-free zone in healthy subjects and nPDR patients was 0.33 ± 0.07 and 0.28 ± 0.1 mm2 (p > 0.05), respectively. The ratio of the INL-free area to the FAZ area in healthy subjects and nPDR patients was 1.08 ± 0.25 and 0.57 ± 0.2 (p < 0.001), respectively. Receiver operating characteristic analysis showed that the ratio of the INL-free area to the FAZ area had the higher area under curve (0.98; 91.7% sensitivity and 97.2% specificity) compared to the FAZ area (0.8; 66.7% sensitivity and 87.1% specificity) for differentiating nPDR from healthy eyes.
Conclusion. This study showed that personalized analysis of the FAZ area based on the relationship between the actual FAZ and INL-free zone has better diagnostic accuracy compared to the conventional FAZ area measurement on OCTA images.
作者简介
Maria Burnasheva
S.M. Kirov Military Medical Academy
编辑信件的主要联系方式.
Email: maria.andreevna1@gmail.com
MD, resident of the ophthalmology department
俄罗斯联邦, Saint PetersburgAlexey Kulikov
S.M. Kirov Military Medical Academy
Email: alexey.kulikov@mail.ru
MD, PhD, DSc, assistant professor, head of the ophthalmology department
俄罗斯联邦, Saint PetersburgDmitrii Maltsev
S.M. Kirov Military Medical Academy
Email: glaz.med@yandex.ru
MD, PhD, ophthalmologist of the ophthalmology department
俄罗斯联邦, Saint Petersburg参考
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