Initial positive first-hand experience of acute keratoconus treatment using platelet-rich serums
- 作者: Khripun K.1, Kobinets Y.2, Rozhdestvenskaya E.1
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隶属关系:
- City Multifield Hospital No. 2
- Academican I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation
- 期: 卷 13, 编号 4 (2020)
- 页面: 67-72
- 栏目: Case reports
- URL: https://journals.rcsi.science/ov/article/view/26058
- DOI: https://doi.org/10.17816/OV26058
- ID: 26058
如何引用文章
详细
Presentation of a clinical case of acute keratoconus treatment by the intracameral platelet-rich plasma administration. Clinical and morphological improvement was registered from the first postoperative day, corneal edema and bullous changes completely resolved during 3 weeks. No side effects were observed. The outcome is confirmed by anterior segment optical coherence tomography data Intracameral platelet-rich autologous plasma administration is a safe and effective method of acute keratoconus treatment.
作者简介
Kirill Khripun
City Multifield Hospital No. 2
Email: kirdoc@mail.ru
MD, Candidate of Medical Sciences, Ophthalmologist, Head of Microsurgery Department No. 3. City Multifield Hospital No. 2
俄罗斯联邦, St. PetersburgYulia Kobinets
Academican I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation
编辑信件的主要联系方式.
Email: juliakobinets@ya.ru
Second Year Ophthalmology Resident, Department of Ophthalmology. Academican I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation
俄罗斯联邦, St. PetersburgElizaveta Rozhdestvenskaya
City Multifield Hospital No. 2
Email: shorie48@gmail.com
Ophthalmologist, Microsurgery Department No. 3. City Multifield Hospital No. 2
俄罗斯联邦, St. Petersburg参考
- Alio JL, Toprak I, Rodriguez AE. Treatment of severe keratoconus hydrops with intracameral platelet-rich plasma injection. Cornea. 2019;38(12):1595-1598. https://doi.org/10.1097/ICO.0000000000002070
- Слонимский Ю.Б., Слонимский А.Ю. Hydrops corneae. Дифференциальная диагностика и лечение // Вестник Оренбургского государственного университета. – 2014. – № 12. – С. 276–281. [Slonimskiy YuB, Slonimskiy AYu. Hydrops corneae. Differencial diagnosis and treatment. Vestnik of the Orenburg state university. 2014;(12):276–281. (In Russ.)]
- Каспаров А.А., Каспарова Е.А., Павлюк А.С. Локальная экспресс-аутоцитокинотерапия (комплекс цитокинов) в лечении вирусных и невирусных поражений глаз // Вестник офтальмологии. – 2004. – T. 120. – № 1. – С. 29–32. [Kasparov AA, Kasparova EA, Pavliuk AS. Local express-autocytocinetherapy (a complex of cytokines) in the treatment of viral and virus-free eye lesions. The Russian annals of ophthalmology. 2014;120(1): 29-32. (In Russ.)]
- Патент РФ на изобретение RU № 2165747 С1. Каспаров А.А., Каспарова Е.А., Павлюк А.С. Способ лечения поствоспалительной буллёзной кератопатии. [Patent RUS № 2165747 S1. Kasparov AA, Kasparova EA, Pavlyuk AS. Sposob lecheniya postvospalitel’noy bullyoznoy keratopatii. (In Russ.)] Доступно по: https://yandex.ru/patents/doc/RU2165747C1_20010427. Ссылка активна на 13.07.2020.
- Патент РФ на изобретение RU № 2357743 C1. Каспаров А.А., Каспарова Е.А., Павлюк А.С. Средство для лечения, способ получения средства для лечения и способ лечения отёка роговицы и других проявлений ранней буллёзной кератопатии. [Patent RUS № 2357743 S1. Kasparov AA, Kasparova EA, Pavlyuk AS. Sredstvo dlya lecheniya, sposob polucheniya sredstva dlya lecheniya i sposob lecheniya oteka rogovitsy i drugikh proyavleniy ranney bulleznoy keratopatii. (In Russ.)] Доступно по: https://patentinform.ru/inventions/reg-2357743.html. Ссылка активна на 13.07.2020.
- Астахов С.Ю., Рикс И.А., Папанян С.С., и др. Опыт клинического применения персонализированной клеточной терапии для лечения больных с первичной эндотелиальной дистрофией после факоэмульсификации // Офтальмологические ведомости. – 2017. – Т. 10. – № 4. – С. 6–12. [Astakhov SYu, Riks IA, Papanyan SS, et al. Experience in personalized cell therapy clinical implementation for treatment of patients with primary endothelial dystrophy after phacoemulsification. Ophthalmology journal. 2017;10(4):6-12. (In Russ.)] https://doi.org/10.17816/ OV1046-12
- Anitua E, Andia I, Ardanza B, et al. Autologous platelets as a source of proteins for healing and tissue regeneration. E Thromb Haemost. 2004;91(1):4-15. https://doi.org/10.1160/TH03-07-0440
- Anitua E, Muruzabal F, Tayebbaet A, et al. Autologous serum and plasmarich in growth factors in ophthalmology: preclinical and clinical studies. Acta Ophthalmol. 2015;93(8):605-614. https://doi.org/10.1111/aos.12710
- Amable PR, Carias RB, Teixeira MV, et al. Platelet-rich plasma preparation for regenerative medicine: Optimization and quantification of cytokines and growth factors. Stem Cell Res Ther. 2013;4(3):67. https://doi.org/10.1186/scrt218
- Lopez-Garcia JS, García-Lozano I, Rivaset L, et al. [Use of autologous serum in ophthalmic practice. (In Spanish)]. Arch Soc Esp Oftalmol. 2007;82(1):9-20. https://doi.org/10.4321/s0365-66912007000100004
- Tsubota K, Goto E, Shimmura S, Shimazaki J. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology. 1999;106(10):1984-1989. https://doi.org/10.1016/S0161-6420(99)90412-8
- Yamada N, Yanai R, Nakamura M, et al. Role of the C domain of IGFs in synergistic promotion, with a substance P-derived peptide, of rabbit corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 2004;45(4):1125-1131. https://doi.org/10.1167/iovs.03-0626
- Федосеева Е.В., Ченцова Е.В., Боровкова Н.В., и др. Морфофункциональные особенности плазмы, богатой тромбоцитами, и ее применение в офтальмологии // Офтальмология. – 2018. – Т. 15. – № 4. – С. 388–393. [Fedoseeva EV, Chentsova EV, Borovkova NV, et al. Morphofunctional peculiarities of platelet rich plasma and its application in ophthalmology. Ophthalmology in Russia. 2018;15(4):388-393. (In Russ.)] https://doi.org/10.18008/1816-5095-2018-4-388-393
- López-Plandolit S, Morales MC, Freire V, et al. Efficacy of plasma rich in growth factors for the treatment of dry eye. Cornea. 2011;30(12):1312-1317. https://doi.org/10.1097/ICO.0b013e31820d86d6
- Giannaccare G, Versura P, Buzzi M, et al. Blood derived eye drops for the treatment of cornea and ocular surface diseases. Transfus Apher Sci. 2017;56(4):595-604. https://doi.org/10.1016/j.transci.2017.07.023
- García-Conca V, Abad-Collado M, Hueso-Abancens JR, et al. Efficacy and safety of treatment of hyposecretory dry eye with platelet-rich plasma. Acta Ophthalmol. 2019;97(2):170-178. https://doi.org/10.1111/aos.13907
- Alio JL, Arnalich-Montiel F, Rodriguez AE. The role of «eye platelet rich plasma» (E-Prp) for wound healing in ophthalmology. Curr Pharm Biotechnol. 2012;13(7):1257-1265. https://doi.org/10.2174/138920112800624355
- Lee JH, Kim MJ, Ha SW, Kim HK. Autologous platelet-rich plasma eye drops in the treatment of recurrent corneal erosions. Korean J Ophthalmol. 2016;30(2):101-107. https://doi.org/10.3341/kjo.2016.30.2.101
- Gehring S, Hoerauf H, Laqua H, et al. Preparation of autologous platelets for the ophthalmologic treatment of macular holes. Transfusion. 1999;39(2):144-148. https://doi.org/10.1046/j.1537-2995.1999.39299154727.x
- Figueroa MS, Govetto A, de Arriba-Palomero P. Short-term results of platelet-rich plasma as adjuvant to 23-G vitrectomy in the treatment of high myopic macular holes. Eur J Ophthalmol. 2016;26(5):491-496. https://doi.org/10.5301/ejo.5000729
- Abdalrahman O, Rodriguez AE, del Barrio JL, Alio JL. Treatment of chronic and extreme ocular hypotension following glaucoma surgery with intraocular platelet-rich plasma: a case report. Eur J Ophthalmol. 2019;29(4):9-12. https://doi.org/10.1177/1120672118803515
- Абугова Т.Д. Клиническая классификация первичного кератоконуса // Современная оптометрия. – 2010. – № 5. – С. 17–20. [Abugova TD. Clinical classifications of primary keratoconus. Sovremennaya optometriya. 2010;(5):17-20. (In Russ.)] https://doi.org/10.17686/sced_rusnauka_2015-179