Антиангиогенная терапия при диабетическом макулярном отёке
- Авторы: Шадричев Ф.Е.1, Григорьева Н.Н.2, Рождественская Е.С.3
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Учреждения:
- ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России
- ФГБОУ ВО «Санкт-Петербургский государственный университет»
- СПбГБУЗ «Городская многопрофильная больница № 2»
- Выпуск: Том 11, № 4 (2018)
- Страницы: 51-66
- Раздел: Статьи
- URL: https://journals.rcsi.science/ov/article/view/11124
- DOI: https://doi.org/10.17816/OV11451-66
- ID: 11124
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Аннотация
Несмотря на то что благодаря улучшению качества обследования и динамического наблюдения в последнее время наблюдается снижение частоты потери зрения, связанной с диабетом, диабетические поражения сетчатки остаются значимой проблемой для мирового здравоохранения. Проблемы со зрением у пациентов, страдающих сахарным диабетом, часто обусловлены развитием макулярного отёка. Ещё недавно золотым стандартом лечения диабетического макулярного отёка являлась лазерная коагуляция сетчатки, которая, как правило, позволяла стабилизировать, но не улучшить остроту зрения. С начала 2000-х гг. наступила фармакологическая эра в терапии этого серьёзного осложнения диабета. Поскольку в патогенезе диабетических поражений сетчатки одну из ключевых ролей играет сосудистый эндотелиальный фактор роста (VEGF), ингибиторы ангиогенеза стали препаратами выбора при лечении макулярного отёка. В статье приводятся результаты исследований, посвящённых анти-VEGF-терапии диабетического макулярного отёка.
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Федор Евгеньевич Шадричев
ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России
Автор, ответственный за переписку.
Email: shadrichev_dr@mail.ru
канд. мед. наук, ассистент кафедры офтальмологии
Россия, Санкт-ПетербургНюргуяна Николаевна Григорьева
ФГБОУ ВО «Санкт-Петербургский государственный университет»
Email: grinur@mail.ru
канд. мед. наук, ассистент кафедры оториноларингологии и офтальмологии
Россия, Санкт-ПетербургЕлизавета Станиславовна Рождественская
СПбГБУЗ «Городская многопрофильная больница № 2»
Email: shorie48@gmail.com
врач-офтальмолог
Россия, Санкт-ПетербургСписок литературы
- World Health Organization. Global Report on Diabetes. Geneva: WHO; 2018.
- International Diabetes Federation. Atlas of diabetes. 8th ed. Brussels: IDF; 2017.
- Lee R, Wong TY, Sabanayagam C. Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vis (Lond). 2015;2:17. doi: 10.1186/s40662-015-0026-2.
- Zheng Y, He M, Congdon N. The worldwide epidemic of diabetic retinopathy. Indian J Ophthalmol. 2012;60(5):428-431. doi: 10.4103/0301-4738.100542.
- Amoaku WM, Saker S, Stewart EA. A review of therapies for diabetic macular oedema and rationale for combination therapy. Eye (Lond). 2015;29(9):1115-1130. doi: 10.1038/eye.2015.110.
- Miller K, Fortun JA. Diabetic Macular Edema: Current Understanding, Pharmacologic Treatment Options, and Developing Therapies. Asia Pac J Ophthalmol (Phila). 2018;7(1):28-35. doi: 10.22608/APO.2017529.
- Romero-Aroca P, Baget-Bernaldiz M, Pareja-Rios A, et al. Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory. J Diabetes Res. 2016;2016:2156273. doi: 10.1155/ 2016/2156273.
- Beaulieu WT, Bressler NM, Melia M, et al. Panretinal Photocoagulation Versus Ranibizumab for Proliferative Diabetic Retinopathy: Patient-Centered Outcomes from a Randomized Clinical Trial. Am J Ophthalmol. 2016;170:206-213. doi: 10.1016/j.ajo.2016.08.008.
- Duh EJ, Sun JK, Stitt AW. Diabetic retinopathy: current understanding, mechanisms, and treatment strategies. JCI Insight. 2017;2(14). doi: 10.1172/jci.insight.93751.
- Schmidt-Erfurth U, Garcia-Arumi J, Bandello F, et al. Guidelines for the Management of Diabetic Macular Edema by the European Society of Retina Specialists (EURETINA). Ophthalmologica. 2017;237(4):185-222. doi: 10.1159/000458539.
- Ogata N, Wang L, Jo N, et al. Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injury. Curr Eye Res. 2001;22(4):245-252. doi: 10.1076/ceyr.22.4.245.5506.
- Simo R, Hernandez C, European Consortium for the Early Treatment of Diabetic R. Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives. Trends Endocrinol Metab. 2014;25(1):23-33. doi: 10.1016/j.tem.2013.09.005.
- Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study research group. Arch Ophthalmol. 1985;103(12):1796-1806. doi: 10.1001/archopht.1985.01050120030015.
- Romero-Aroca P. Managing diabetic macular edema: The leading cause of diabetes blindness. World J Diabetes. 2011;2(6):98-104. doi: 10.4239/wjd.v2.i6.98.
- Bahrami B, Hong T, Gilles MC, et al. Anti-VEGF Therapy for diabetic eye diseases. Asia-Pac J Ophthalmol. 2017;6:535-545.
- Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 1996;380(6573):439-442. doi: 10.1038/380439a0.
- Ferrara N. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int. 1999;56(3):794-814. doi: 10.1046/j.1523-1755.1999.00610.x.
- Ferrara N. VEGF-A: a critical regulator of blood vessel growth. Eur Cytokine Netw. 2009;20(4):158-163. doi: 10.1684/ecn.2009.0170.
- Freedman SB, Isner JM. Therapeutic angiogenesis for coronary artery disease. Ann Intern Med. 2002;136(1):54-71. doi: 10.7326/0003-4819-136-1-200201010-00011.
- Jin K, Zhu Y, Sun Y, et al. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci USA. 2002;99(18):11946-11950. doi: 10.1073/pnas.182296499.
- Takahashi H, Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (Lond). 2005;109(3):227-241. doi: 10.1042/CS20040370.
- Wang J, Xu X, Elliott MH, et al. Muller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes. 2010;59(9):2297-2305. doi: 10.2337/db09-1420.
- Witmer AN, Blaauwgeers HG, Weich HA, et al. Altered expression patterns of VEGF receptors in human diabetic retina and in experimental VEGF-induced retinopathy in monkey. Invest Ophthalmol Vis Sci. 2002;43(3):849-857.
- Zhang X, Bao S, Lai D, et al. Intravitreal triamcinolone acetonide inhibits breakdown of the blood-retinal barrier through differential regulation of VEGF-A and its receptors in early diabetic rat retinas. Diabetes. 2008;57(4):1026-1033. doi: 10.2337/db07-0982.
- Papadopoulos N, Martin J, Ruan Q, et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012;15(2):171-185. doi: 10.1007/s10456-011-9249-6.
- Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994;331(22):1480-1487. doi: 10.1056/NEJM199412013312203.
- Funatsu H, Yamashita H, Nakamura S, et al. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmology. 2006;113(2):294-301. doi: 10.1016/j.ophtha.2005.10.030.
- Autiero M, Waltenberger J, Communi D, et al. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med. 2003;9(7):936-943. doi: 10.1038/nm884.
- Bry M, Kivela R, Leppanen VM, Alitalo K. Vascular endothelial growth factor-B in physiology and disease. Physiol Rev. 2014;94(3):779-794. doi: 10.1152/physrev.00028.2013.
- Nguyen QD, De Falco S, Behar-Cohen F, et al. Placental growth factor and its potential role in diabetic retinopathy and other ocular neovascular diseases. Acta Ophthalmol. 2018;96(1):e1-e9. doi: 10.1111/aos.13325.
- Kovacs K, Marra KV, Yu G, et al. Angiogenic and Inflammatory Vitreous Biomarkers Associated With Increasing Levels of Retinal Ischemia. Invest Ophthalmol Vis Sci. 2015;56(11):6523-6530. doi: 10.1167/iovs.15-16793.
- Kinoshita S, Noda K, Saito W, et al. Vitreous levels of vascular endothelial growth factor-B in proliferative diabetic retinopathy. Acta Ophthalmol. 2016;94(6): e521-523. doi: 10.1111/aos.12969.
- Zhong X, Huang H, Shen J, et al. Vascular endothelial growth factor-B gene transfer exacerbates retinal and choroidal neovascularization and vasopermeability without promoting inflammation. Mol Vis. 2011;17:492-507.
- Bressler NM, Beck RW, Ferris FL, 3rd. Panretinal photocoagulation for proliferative diabetic retinopathy. N Engl J Med. 2011;365(16):1520-1526. doi: 10.1056/NEJMct0908432.
- Diabetic Retinopathy Study Research Group. Photocoagulation treatment of proliferative diabetic retinopathy. Clinical application of Diabetic Retinopathy Study (DRS) findings, DRS Report Number 8. Ophthalmology. 1981;88(7):583-600. doi: 10.1016/S0161-6420(81)34978-1.
- Duh EJ, Yang HS, Suzuma I, et al. Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. Invest Ophthalmol Vis Sci. 2002;43(3):821-829.
- Hattenbach LO, Beck KF, Pfeilschifter J, et al. Pigment-epithelium-derived factor is upregulated in photocoagulated human retinal pigment epithelial cells. Ophthalmic Res. 2005;37(6):341-346. doi: 10.1159/000088263.
- Ogata N, Ando A, Uyama M, Matsumura M. Expression of cytokines and transcription factors in photocoagulated human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol. 2001;239(2):87-95. doi: 10.1007/s004170000235.
- Freund KB, Korobelnik JF, Devenyi R, et al. Treat-and-extend regimens with anti-VEGF agents in retinal diseases. Retina. 2015;35(8):1489-1506. doi: 10.1097/IAE. 0000000000000627.
- Lanzetta P, Loewenstein A, Vision Academy Steering C. Fundamental principles of an anti-VEGF treatment regimen: optimal application of intravitreal anti-vascular endothelial growth factor therapy of macular diseases. Graefes Arch Clin Exp Ophthalmol. 2017;255(7):1259-1273. doi: 10.1007/s00417-017-3647-4.
- Massin P, Bandello F, Garweg JG, et al. Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study. Diabetes Care. 2010;33(11):2399-2405. doi: 10.2337/dc10-0493.
- Mitchell P, Bandello F, Schmidt-Erfurth U, et al. The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology. 2011;118(4):615-625. doi: 10.1016/j.ophtha. 2011.01.031.
- Nguyen QD, Brown DM, Marcus DM, et al. Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology. 2012;119(4):789-801. doi: 10.1016/j.ophtha.2011.12.039.
- Brown DM, Schmidt-Erfurth U, Do DV, et al. Intravitreal Aflibercept for Diabetic Macular Edema: 100-Week Results from the VISTA and VIVID Studies. Ophthalmology. 2015;122(10):2044-2052. doi: 10.1016/j.ophtha.2015.06.017.
- Heier JS, Korobelnik JF, Brown DM, et al. Intravitreal Aflibercept for Diabetic Macular Edema: 148-Week Results from the VISTA and VIVID Studies. Ophthalmology. 2016;123(11):2376-2385. doi: 10.1016/j.ophtha.2016.07.032.
- Korobelnik JF, Do DV, Schmidt-Erfurth U, et al. Intravitreal aflibercept for diabetic macular edema. Ophthalmology. 2014;121(11):2247-2254. doi: 10.1016/j.ophtha.2014.05.006.
- Wells JA, Glassman AR, Ayala AR, et al. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. N Engl J Med. 2015;372(13):1193-1203. doi: 10.1056/NEJMoa1414264.
- Wells JA, Glassman AR, Ayala AR, et al. Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema: Two-Year Results from a Comparative Effectiveness Randomized Clinical Trial. Ophthalmology. 2016;123(6):1351-1359. doi: 10.1016/j.ophtha.2016.02.022.
- Jampol LM, Glassman AR, Bressler NM, et al. Anti-Vascular Endothelial Growth Factor Comparative Effectiveness Trial for Diabetic Macular Edema: Additional Efficacy Post Hoc Analyses of a Randomized Clinical Trial. JAMA Ophthalmol. 2016;134(12). doi: 10.1001/jamaophthalmol.2016.3698.
- Bressler SB, Liu D, Glassman AR, et al. Change in Diabetic Retinopathy Through 2 Years: Secondary Analysis of a Randomized Clinical Trial Comparing Aflibercept, Bevacizumab, and Ranibizumab. JAMA Ophthalmol. 2017;135(6):558-568. doi: 10.1001/jamaophthalmol.2017.0821.
- Bressler SB, Glassman AR, Almukhtar T, et al. Five-Year Outcomes of Ranibizumab With Prompt or Deferred Laser Versus Laser or Triamcinolone Plus Deferred Ranibizumab for Diabetic Macular Edema. Am J Ophthalmol. 2016;164:57-68. doi: 10.1016/j.ajo.2015.12.025.
- Elman MJ, Bressler NM, Qin H, et al. Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2011;118(4):609-614. doi: 10.1016/j.ophtha.2010.12.033.
- Elman MJ, Aiello LP, Beck RW, et al. Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2010;117(6):1064-1077.e35. doi: 10.1016/j.ophtha.2010.02.031.
- Diabetic Retinopathy Clinical Research Network, Elman MJ, Qin H, et al. Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment: three-year randomized trial results. Ophthalmology. 2012;119(11):2312-2318. doi: 10.1016/j.ophtha.2012.08.022.
- Bressler NM, Beaulieu WT, Glassman AR, et al. Persistent Macular Thickening Following Intravitreous Aflibercept, Bevacizumab, or Ranibizumab for Central-Involved Diabetic Macular Edema with Vision Impairment: A Secondary Analysis of a Randomized Clinical Trial. JAMA Ophthalmol. 2018;136(3):257-269. doi: 10.1001/jamaophthalmol.2017.6565.
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