Predicting the course of uveitis against the background of juvenile idiophatic arthritis when using topical therapy regimens. The results of mathematical modeling
- Authors: Chasnyk V.G.1, Kononov A.V.1,2, Brzheskiy V.V.1, Gaidar E.V.1, Kalashnikova O.V.1, Dubko M.F.1, Kostik M.M.1, Masalova V.V.1, Snegireva L.S.1, Nikitina T.N.1, Kononova N.E.1
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Affiliations:
- Saint Petersburg State Pediatric Medical University
- North-West State Medical University named after I.I. Mechnikov
- Issue: Vol 17, No 2 (2024)
- Pages: 21-29
- Section: Original researches
- URL: https://journals.rcsi.science/ov/article/view/262996
- DOI: https://doi.org/10.17816/OV628282
- ID: 262996
Cite item
Abstract
BACKGROUND: Juvenile idiopathic arthritis is the most common rheumatic disease in children, and uveitis is its most destructive extra-articular manifestation. Despite the existence of Federal clinical guidelines for the management of these patients, their treatment is largely based on the experience of doctors and varies greatly even within the same country.
AIM: The aim of the study is to find factors for predicting the course of uveitis and optimizing therapy.
MATERIALS AND METHODS: The case histories of 150 children aged 1.5 to 17 years with active uveitis in the structure of juvenile arthritis were analyzed using multifactorial modeling (construction of classification trees).
RESULTS: The fact of a significant influence of the time elapsed from the onset of rheumatic disease and uveitis until the start of therapy by genetically engineered medications (tumor necrosis factor alpha inhibitors) in treatment programs has been established.
CONCLUSIONS: Thus, the inclusion of this factor into the group of controlling ones makes it possible to achieve inactive uveitis status after 1, 3, and 6 months in a higher percentage of cases. However, the obtained data still require additional clinical confirmation.
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##article.viewOnOriginalSite##About the authors
Vyacheslav G. Chasnyk
Saint Petersburg State Pediatric Medical University
Email: chasnyk@gmail.com
ORCID iD: 0000-0001-5776-1490
SPIN-code: 8175-0010
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Saint PetersburgAnatolii V. Kononov
Saint Petersburg State Pediatric Medical University; North-West State Medical University named after I.I. Mechnikov
Email: 7435020@gmail.com
ORCID iD: 0000-0002-4673-5024
Russian Federation, Saint Petersburg; Saint Petersburg
Vladimir V. Brzheskiy
Saint Petersburg State Pediatric Medical University
Email: vvbrzh@yandex.ru
ORCID iD: 0000-0001-7361-0270
SPIN-code: 5442-0989
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Saint PetersburgEkaterina V. Gaidar
Saint Petersburg State Pediatric Medical University
Email: gaidare85@gmail.com
ORCID iD: 0000-0002-0971-2018
SPIN-code: 1625-9960
MD, Cand. Sci. (Medicine)
Russian Federation, Saint PetersburgOlga V. Kalashnikova
Saint Petersburg State Pediatric Medical University
Email: koira7@yandex.ru
ORCID iD: 0000-0002-8683-4270
SPIN-code: 9114-0435
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, Saint PetersburgMargarita F. Dubko
Saint Petersburg State Pediatric Medical University
Email: andrq@rambler.ru
ORCID iD: 0000-0002-6834-1413
SPIN-code: 4152-4976
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, Saint PetersburgMikhail M. Kostik
Saint Petersburg State Pediatric Medical University
Email: kost-mikhail@yandex.ru
ORCID iD: 0000-0002-1180-8086
SPIN-code: 7257-0795
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Saint PetersburgVera V. Masalova
Saint Petersburg State Pediatric Medical University
Email: masalova.vera@gmail.com
ORCID iD: 0000-0002-3703-4920
SPIN-code: 2241-3508
Russian Federation, Saint Petersburg
Ludmila S. Snegireva
Saint Petersburg State Pediatric Medical University
Email: l.s.snegireva@mail.ru
ORCID iD: 0000-0001-6778-4127
Russian Federation, Saint Petersburg
Tatiana N. Nikitina
Saint Petersburg State Pediatric Medical University
Email: nikitina.tat.nik@yandex.ru
ORCID iD: 0000-0001-6758-6999
SPIN-code: 8496-2970
MD, Cand. Sci. (Medicine)
Russian Federation, Saint PetersburgNadezhda E. Kononova
Saint Petersburg State Pediatric Medical University
Author for correspondence.
Email: Nali-6@yandex.ru
ORCID iD: 0000-0002-2145-1762
SPIN-code: 7217-3582
MD, Cand. Sci. (Medicine)
Russian Federation, Saint PetersburgReferences
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