Regional hemodynamics characteristics in patients with non-arteritic anterior ischemic optic neuropathy
- Authors: Antonov V.A.1, Rukhovets A.G.1, Astakhov S.Y.1, Kozlova Y.V.1, Sharma A.A.1
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Affiliations:
- Pavlov First St. Petersburg State Medical University
- Issue: Vol 15, No 1 (2022)
- Pages: 29-37
- Section: Original researches
- URL: https://journals.rcsi.science/ov/article/view/107011
- DOI: https://doi.org/10.17816/OV107011
- ID: 107011
Cite item
Abstract
BACKGROUND: Non-arteritic anterior ischemic optic neuropathy (NAION) takes the first place in the total amount of acute vascular optic neuropathy cases. There is no common understanding of pathogenetic mechanisms of disease. This is largely due to the absence of direct optic nerve head blood flow registration method in ophthalmology.
AIM: The aim of this work is to evaluate ocular hemodynamics using different methods in patients with non-arteritic anterior ischemic optic neuropathy (NAION).
MATERIALS AND METHODS: 73 patients were enrolled in the study. 46 patients (46 eyes) with NAION were included in the first group. Control group was composed of 27 patients (50 eyes) with systemic risk factors of NAION without any retinal and optic nerve diseases. Regional hemodynamics parameters were evaluated with ophthalmosphigmography, ophthalmoplethysmography, ophthalmoreography, OCT-angiography and EDI-OCT.
RESULTS: Blood flow values in different parts of the choroid did not statistically differ between groups when using ophthalmosphigmography, ophthalmoplethysmography, ophthalmoreography methods. Radial peripapillary capillaries in optic nerve head area were evaluated, and statistically significant difference was found in all sectors.
CONCLUSION: The main component of NAION pathogenesis is a decreasing perfusion pressure in paraoptic short posterior ciliary arteries. Blood flow in choroid does not play an important role in the disease pathogenesis.
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##article.viewOnOriginalSite##About the authors
Vladimir A. Antonov
Pavlov First St. Petersburg State Medical University
Email: antonov@alborada.fi
ORCID iD: 0000-0002-5823-8367
Postgraduate Student
Russian Federation, Saint PetersburgAlexey G. Rukhovets
Pavlov First St. Petersburg State Medical University
Email: arukhovets@gmail.com
ORCID iD: 0000-0001-6240-9395
SPIN-code: 1348-7444
Scopus Author ID: 57194340940
Cand.Sci.(Med.)
Russian Federation, Saint PetersburgSergey Yu. Astakhov
Pavlov First St. Petersburg State Medical University
Author for correspondence.
Email: astakhov73@mail.ru
ORCID iD: 0000-0003-0777-4861
SPIN-code: 7732-1150
Scopus Author ID: 56660518500
Dr. Sci. (Med.), Professor
Russian Federation, Saint PetersburgYulya V. Kozlova
Pavlov First St. Petersburg State Medical University
Email: yulyashak@mail.ru
Student
Russian Federation, Saint PetersburgAnton A. Sharma
Pavlov First St. Petersburg State Medical University
Email: saa98@mail.ru
ORCID iD: 0000-0003-4849-7004
Student
Russian Federation, Saint PetersburgReferences
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