Asymmetric features of keratopathy associated with pseudoexfoliation syndrome

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Abstract

In this article, using a clinical case as example we report clinical features of keratopathy associated with pseudoexfoliation syndrome, as well as pathological changes found by confocal microscopy.

About the authors

Vitaly V. Potyomkin

Pavlov First Saint Petersburg State Medical University; City Multi-Field Hospital No. 2

Email: potem@inbox.ru

PhD, Assistant Professor. Department of Ophthalmology; ophthalmologist

Russian Federation, 6/8, Lva Tolstogo street, St. Petersburg, 197089; St. Petersburg, Uchebniy pereulok, 5  

Elena V. Goltsman

 City Ophthalmologic Center of City hospital N 2

Author for correspondence.
Email: ageeva_elena@inbox.ru

ophthalmologist

Russian Federation,  St. Petersburg, Uchebniy pereulok, 5

Tat’yana S. Varganova

City Ophthalmologic Center of City hospital № 2

Email: varganova.ts@yandex.ru

PhD, Ophthalmologist

Russian Federation, St. Petersburg, Uchebniy pereulok, 5

Dmitriy F. Belov

 City Ophthalmologic Center of City hospital № 2

Email: belovd1990@gmail.com

ophthalmologist

Russian Federation,  St. Petersburg, Uchebniy pereulok, 5.

Farhod O. Kasymov

City Multi-Field Hospital No. 2; North-Western State Medical University named after I.I. Mechnikov

Email: farkkas@yahoo.com

ophthalmologist; Assistant of the Ophthalmology Department

Russian Federation, St. Petersburg, Uchebniy pereulok, 5; St. Petersburg, Kirochnaya street  41  

References

  1. Naumann GOH, Schlötzer-Schrehardt U. Keratopathy in pseudoexfoliation syndrome as a cause of corneal endothelial decompensation. Ophthalmology. 2000;107(6):1111-1124. doi: https://doi.org/10.1016/s0161-6420(00)00087-7.
  2. Zheng X, Shiraishi A, Okuma S, et al. In vivo confocal microscopic evidence of keratopathy in patients with pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci. 2011;52(3):1755-1761. doi: https://doi.org/10.1167/iovs.10-6098.
  3. Ritch R, Schlötzer-Schrehardt U. Exfoliation syndrome. Surv Ophthalmol. 2001;45(4):265-315. doi: https://doi.org/10.1016/s0039-6257(00)00196-x.
  4. Schlötzer-Schrehardt U, Naumann GO. Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol. 2006;141(5):921-937. doi: https://doi.org/10.1016/j.ajo.2006.01.047.
  5. Потёмкин В.В., Варганова Т.С., Терехова И.В., Агеева Е.В. Влияние факоэмульсификации на состояние различных слоёв эпителия роговой оболочки у пациентов с псевдоэксфолиативным синдромом по данным конфокальной микроскопии in vivo // Офтальмологические ведомости. – 2017. – Т. 10. – № 3. – С. 29-34. [Potemkin VV, Varganova TS, Terekhova IV, Ageeva EV. The influence of phacoemulsification on various corneal layers in patients with pseudoexfoliation syndrome assessed with confocal in vivo microscopy. Ophthalmology Journal. 2017;10(3):29-34. (In Russ.)]. doi: https://doi.org/10.17816/OV10329-34.
  6. Потёмкин В.В., Варганова Т.С., Акопов Е.Л., Агеева Е.В. Влияние псевдоэксфолиативного синдрома на морфологические свойства роговицы по данным конфокальной in vivo микроскопии // Офтальмологические ведомости. – 2017. – Т. 10. – № 2. – С. 49-55. [Potemkin VV, Varganova TS, Akopov EL, Ageeva EV. The influence of pseudoexfoliative syndrome on corneal morphology based on in vivo confocal microscopy. Ophthalmology Journal. 2017;10(2):49-55. (In Russ.)]. doi: https://doi.org/10.17816/OV10249-55.
  7. Zheng X, Inoue Y, Shiraishi A, et al. In vivo confocal microscopic and histological findings of unknown bullous keratopathy probably associated with pseudoexfoliation syndrome. BMC Ophthalmol. 2012;12:17. doi: https://doi.org/10.1186/1471-2415-12-17.
  8. Wirbelauer C, Anders N, Pham DT, Wollensak J. Corneal endothelial cell changes in pseudoexfoliation syndrome after cataract surgery. Arch Ophthalmol. 1998;116(2):145-149. doi: https://doi.org/10.1001/archopht.116.2.145.
  9. Wirbelauer C, Anders N, Pham DT, et al. Early postoperative endothelial cell loss after corneoscleral tunnel incision and phacoemulsification in pseudoexfoliation syndrome. Ophthalmologe. 1997;94(5):332-336. doi: https://doi.org/10.1007/s003470050124.
  10. Inoue K. Morphological study of corneal endothelium and corneal thickness in pseudoexfoliation syndrome. Jpn J Ophthalmol. 2003;47(3):235-239. doi: https://doi.org/10.1016/s0021-5155(03)00022-4.
  11. Ostern AE, Drolsum L. Corneal endothelial cells 6-7 years following cataract surgery in patients with pseudoexfoliation syndrome. Acta Ophthalmol. 2012;90(5):408-411. doi: https://doi.org/10.1111/j.1755-3768.2010.02012.x.
  12. Zheng X. New findings for an old disease: morphological studies on pseudoexfoliation syndrome-related keratopathy and binocular asymmetry. Cornea. 2013;32 Suppl 1: S84-90. doi: https://doi.org/10.1097/ICO.0b013e3182a3657d.

Supplementary files

Supplementary Files
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2. Fig. 1. Anterior segment: а, c – right eye; b, d – left eye

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3. Fig. 2. Endothelial microscopy of patient: a – right eye; b – left eye

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4. Fig. 3. Confocal microscopy of the left eye

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5. Fig. 4. Confocal microscopy of the right eye

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Copyright (c) 2019 Potyomkin V.V., Goltsman E.V., Varganova T.S., Belov D.F., Kasymov F.O.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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