Anti-vegf therapy in treatment of vitreous hemorrhage due to proliferative diabetic retinopathy

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Abstract

Purpose. To investigate the possibility of anti-VEGF therapy use in treatment of vitreous hemorrhage due to proliferative diabetic retinopathy without signs of vitreoretinal traction.

Materials and methods. In this case series study, 8 patients with severe vitreous hemorrhage due to proliferative diabetic retinopathy without signs of vitreoretinal traction were treated with intravitreal ranibizumab injections using treat-and-extend regimen. Patients were followed for 12–54 months.

Results. . Intravitreal ranibizumab injections using treat-and-extend regimen promoted a complete resolution of vitreous hemorrhage in one month after the 2nd or the 3rd monthly ranibizumab injection, followed by a significant visual acuity improvement.

Conclusion. Anti-VEGF therapy using treat-and-extend regimen could be recommended for treatment of vitreous hemorrhage due to proliferative diabetic retinopathy without signs of vitreoretinal traction.

About the authors

Aysylu B. Galimova

Russian Centre for Eye and Plastic Surgery

Author for correspondence.
Email: aible@mail.ru
ORCID iD: 0000-0001-7311-0954
SPIN-code: 2098-1918

MD, PhD, Cand. Sci. (Med.), Head of Ophthalmology Department, Russian Centre for Eye and Plastic Surgery of the Ministry of Healthcare of the Russian Federation

Russian Federation, Ufa

Venera U. Galimova

Bashkir State Medical University

Email: galimova.v@mail.ru
ORCID iD: 0000-0002-1610-108X

MD, PhD, Dr. Sci. (Med.), Professor, Chair Professor of Department of Opthalmology with PEI Course. Bashkir State Medical University of the Ministry of Healthcare of the Russian Federation

Russian Federation, Ufa

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2. Patient I., female, 55 years old, presented with a sudden loss of vision of her right eye in December 2016. The patient had a history of insulin-dependent type 2 diabetes mellitus. Visual acuity upon presentation was 0.02, no correction possible. B-scan ultrasound examination (a, b) showed severe vitreous hemorrhage. In 1 month after the third monthly intravitreal ranibizumab injection, a complete resolution of vitreous hemorrhage was found (c, d), accompanied by an improvement of visual acuity up to 0.3, no correction possible

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Copyright (c) 2020 Galimova A.B., Galimova V.U.

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