Original two-component fibrin glue preparation technique for use in ophthalmic surgery

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Abstract

The study is aimed to modifying the method of a two-component fibrin glue production, as well as studying the possibility of applying glue fixation of the amniotic membrane to the stroma of the cornea, in comparison with interrupted sutures. An experimental study allowed us to determine the optimal composition of the first (base) and second (activating) components, to modify the method for fibrin glue production, and also to test in vivo in six Chinchilla rabbits the fixation of the amniotic membrane using the proposed protocol. The resulting fibrin glue allows not only to securely fix the amniotic membrane to the stroma of the cornea, to reduce the time of the procedure, but also to create conditions for an earlier onset of epithelization while maintaining the transparency of the cornea compared to suture fixation.

About the authors

Alexey N. Kulikov

S.M. Kirov Military Medical Academy

Email: alexey.kulikov@mail.ru
SPIN-code: 6440-7706

MD, PhD, DMedSc, Professor, Head of the Department. Ophthalmology Department

Russian Federation, 6G, Akademika Lebedeva street, Saint-Petersburg, 194044

Sergey V. Churashov

S.M. Kirov Military Medical Academy

Email: Churashoff@mail.ru

MD, PhD, DMedSc, Assistant Professor. Ophthalmology Department

Russian Federation, 6G, Akademika Lebedeva street, Saint-Petersburg, 194044

Anna Yu. Kuznetsova

S.M. Kirov Military Medical Academy

Author for correspondence.
Email: anutka.kuznetsova@gmail.com
ORCID iD: 0000-0001-9957-1804
SPIN-code: 1708-1765

Ophthalmologist

Russian Federation, 6G, Akademika Lebedeva street, Saint-Petersburg, 194044

Ilia O. Gavriluk

S.M. Kirov Military Medical Academy

Email: iluaayaks@gmail.com

Ophthalmologist

Russian Federation, 6G, Akademika Lebedeva street, Saint-Petersburg, 194044

References

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2. Fig. 1. Оptical coherence tomography on the 30th day after surgery

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Copyright (c) 2019 Kulikov A.N., Churashov S.V., Kuznetsova A.Y., Gavriluk I.O.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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