Modern strategy and standards of treatment of lower eyelid skin malignant neoplasms

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Cases of surgical treatment of basal cell skin carcinoma of the lower eyelid are rarely described in the world literature. Perhaps this is due to the search for new non-surgical treatment methods or to the fact that this localization is poorly represented in the total incidence of basal cell skin cancer. However, the operative method, recommended as the main line of treatment by both domestic and foreign clinical recommendations, is still recognized as the most radical and aesthetically acceptable method of treatment. Non-radical treatment of the tumor leads, in turn, to relapses of the disease, to the emergence of systemic metastatic foci due to the lymphogenic and hematogenic spread of tumor cells. In the article we describe the experience of surgical treatment of patients suffering from basal cell skin carcinoma of the lower eyelid of varying degrees of extension.

About the authors

Andrey P. Polyakov

P. Hertsen Moscow Oncology Research Institute is a branch of the National Medical Research Center for Radiology

Email: appolyakov@mail.ru
ORCID iD: 0000-0003-2095-5931

MD, Dr. Sci. (Med.), head of the Department of microsurgery

Russian Federation, Moscow

Dmitry V. Davydov

P. Hertsen Moscow Oncology Research Institute is a branch of the National Medical Research Center for Radiology

Email: davydov_dmvk@pfur.ru
ORCID iD: 0000-0001-5506-6021

MD, Dr. Sci. (Med.), head of the Department of oncoplastic surgery

Russian Federation, Moscow

Irina V. Novikova

P. Hertsen Moscow Oncology Research Institute is a branch of the National Medical Research Center for Radiology

Email: rebrikovaiv@mail.ru
ORCID iD: 0000-0002-7854-9824

Cand. Sci. (Med.), senior research associate of the Department of microsurgery

Russian Federation, Moscow

Adam L. Sugaipov

P. Hertsen Moscow Oncology Research Institute is a branch of the National Medical Research Center for Radiology

Email: Al.Sugaipov@mail.ru
ORCID iD: 0000-0002-9349-7372

physician of Department of microsurgery

Russian Federation, Moscow

Olga S. Kuznetsova

P. Hertsen Moscow Oncology Research Institute is a branch of the National Medical Research Center for Radiology

Email: olga-sudalenko@yandex.ru
ORCID iD: 0000-0003-1789-4007

pathologist of pathoanatomical Department

Russian Federation, Moscow

Elena A. Naumova

P. Hertsen Moscow Oncology Research Institute is a branch of the National Medical Research Center for Radiology

Author for correspondence.
Email: dr.naumova@outlook.com
ORCID iD: 0000-0001-8203-7971

clinical resident of Department of microsurgery

Russian Federation, Moscow

References

  1. Weissferdt A, Kalhor N, Moran CA. Cutaneous basal cell carcinoma with distant metastasis to thorax and bone: A clinicopathological and immunohistochemical study of 15 cases. Virchows Arch. 2017;470(6):687–694. doi: 10.1007/s00428-017-2121-3
  2. Monroe M, Kakarala K. Management of advanced basal cell carcinoma of the head and neck. Otolaryngol Clin North Am. 2021;54(2):271–280. doi: 10.1016/j.otc.2020.11.003
  3. Phan K, Oh LJ, Goyal S, et al. Recurrence rates following surgical excision of periocular basal cell carcinomas: systematic review and meta-analysis. J Dermatolog Treat. 2020;31(6):597–601. doi: 10.1080/09546634.2019.1698702
  4. Obshcherossiiskii natsional’nyi soyuz “Assotsiatsiya onkologov Rossii”, Assotsiatsiya spetsialistov po problemam melanomy, Obshcherossiiskaya obshchestvennaya organizatsiya “Rossiiskoe obshchestvo klinicheskoi onkologii”, Obshcherossiiskaya obshchestvennaya organizatsiya “Assotsiatsiya vrachei-oftalmologov”. Klinicheskie rekomendatsii “Bazalnokletochnyi rak kozhi”. 2020. 85 p. (In Russ.)
  5. Vaccari S, Barisani A, Schiavi C, et al. Basal cell carcinoma of the eyelid margin: Dermoscopic clues in a case series. Dermatol Ther. 2021;34(4): e15006. doi: 10.1111/dth.15006
  6. Brovkina AF, Lerner MYu. Eyelid skin cancer: еpidemiology, prognosis. Head and Neck Tumors (HNT). 2017;7(1):81–85. (In Russ.) doi: 10.17650/2222-1468-2017-7-1-81-85
  7. Silverman N, Shinder R. What’s new in eyelid tumors. Asia Pac J Ophthalmol (Phila). 2017;6(2):143–152. doi: 10.22608/APO.201701
  8. Lai V, Cranwell W, Sinclair R. Epidemiology of skin cancer in the mature patient. Clin Dermatol. 2018;36(2):167–176. doi: 10.1016/j.clindermatol.2017.10.008
  9. Leffell DJ, Carucci JA. Management of Skin Cancer. DeVita VT, Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Onco logy. 6th edition. Philadelphia PA: Lippincott Williams & Wilkins; 2001.
  10. Furdova A, Lukacko P. Periocular basal cell carcinoma predictors for recurrence and infiltration of the orbit. J Craniofac Surg. 2017;28(1): e84–e87. doi: 10.1097/SCS.0000000000003242
  11. Prídavková Z, Bieliková A, Ferková N, Lysková D. Recurrent periocular basal cell carcinoma. Case report. Cesk Slov Oftalmol. 2021;77(4):208–213. doi: 10.31348/2021/24
  12. Weesie F, Naus NC, Vasilic D, et al. Recurrence of periocular basal cell carcinoma and squamous cell carcinoma after Mohs micrographic surgery: a retrospective cohort study. Br J Dermatol. 2019;180(5):1176–1182. doi: 10.1111/bjd.17516
  13. Leibovitch I, McNab A, Sullivan T, et al. Orbital invasion by periocular basal cell carcinoma. Ophthalmology. 2005;112(4):717–723. doi: 10.1016/j.ophtha.2004.11.036
  14. Kim DP, Kus KJB, Ruiz E. Basal cell carcinoma review. Hematol Oncol Clin North Am. 2019;33(1):13–24. doi: 10.1016/j.hoc.2018.09.004
  15. Iuliano A, Strianese D, Uccello G, et al. Risk factors for orbital exenteration in periocular Basal cell carcinoma. Am J Ophthalmol. 2012;153(2):238–241.e1. doi: 10.1016/j.ajo.2011.08.004
  16. Sun MT, Wu A, Figueira E, et al. Management of periorbital basal cell carcinoma with orbital invasion. Future Oncol. 2015;11(22): 3003–3010. doi: 10.2217/fon.15.190
  17. Mehta KS, Mahajan VK, Chauhan PS, et al. Metastatic Basal cell carcinoma: a biological continuum of Basal cell carcinoma? Case Rep Dermatol Med. 2012;2012:157187. doi: 10.1155/2012/157187

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Appearance of the patient before surgery (September, 2020)

Download (71KB)
Indexing metadata
3. Fig. 2. Intraoperative photos of the patient on October 13, 2020: a — appearance of the surgical area after the tumor removal of; b — aspect of the surgical area, moved flap fixed by interrupted sutures

Download (208KB)
Indexing metadata
4. Fig. 3. Photo of the histological specimen of the patient's postoperative material, hematoxylin and eosin staining, ×100

Download (171KB)
Indexing metadata
5. Fig. 4. Appearance of the patient 2 years after surgery

Download (59KB)
Indexing metadata
6. Fig. 5. Appearance of the patient on February, 2021 (before surgery): a — front view; b —left view

Download (183KB)
Indexing metadata
7. Fig. 6. Intraoperative photos of the patient on March 11, 2021: a — front view of the patient after the tumor removal, preoperative marking of flaps (paramedian, buccal-zygomatic adipo-cutaneous flaps) has been performed; b — left view of the patient after the tumor removal, preoperative marking of flaps (paramedian, buccal-zygomatic adipo-cutaneous flaps) has been performed; c — appearance of the surgical area, paramedian, buccal-zygomatic and buccal adipo-cutaneous flaps have been mobilized; d — the appearance of the surgical area, paramedian, buccal-zygomatic and buccal skin-fat flaps were moved to the area of the formed postoperative defect and fixed with interrupted sutures

Download (274KB)
Indexing metadata
8. Fig. 7. Appearance of the patient in the delayed postoperative period after the first stage of surgical treatment: a — front view; b —left view

Download (201KB)
Indexing metadata
9. Fig. 8. Intraoperative photo of the patient on July 28, 2021. Second stage of surgical treatment — correction of the displaced paramedian flap

Download (119KB)
Indexing metadata
10. Fig. 9. Appearance of the patient in remote postoperative period, after the second stage of surgical treatment: a — front view; b —left view

Download (176KB)
Indexing metadata
11. Fig. 10. Appearance of the patient in remote postoperative period, after the second stage of surgical treatment: a — front view with eyes opened; b — front view with eyes closed

Download (157KB)
Indexing metadata
12. Fig. 11. Appearance of the patient before surgery: a — left view; b — front view

Download (133KB)
Indexing metadata
13. Fig. 12. Intraoperative photos of the patient on June 24, 2021: a — view of the formed postoperative tissue defect, a wedge resection of the lower eyelid was performed; b — appearance of the postoperative wound, wound edges are closed in layers

Download (154KB)
Indexing metadata
14. Fig. 13. Appearance of the patient on September, 2022: a — left view; b — front view

Download (111KB)
Indexing metadata

Copyright (c) 2023 Polyakov A.P., Davydov D.V., Novikova I.V., Sugaipov A.L., Kuznetsova O.S., Naumova E.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies