Сases of lacrimal system affection after Coronavirus infection

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

In the present article, cases of lacrimal apparatus conditions emerging after a new Coronavirus infection COVID-19. The aim of the study is to determine the causes of epiphora in patients after Coronavirus infection.

26 patients (30 eyes) were examined, aged from 28 to 70 years, complaining of tearing, which emerged for the first time ever not earlier than 5–14 days from the onset of the laboratory-confirmed Coronavirus infection COVID-19, which had a mild or a moderately severe course and was accompanied by anosmia.

In patients, following conditions of the lacrimal system were revealed: in 22 patients, there were pathological changes of the horizontal portion of lacrimal pathways; in 6 people dry eye syndrome was diagnosed: in 3 people, it was of mild severity, manifested by hyperlacrimia, 3 people had moderate severity of the dry eye syndrome. As concomitant, following signs were revealed: in 7 patients — rhinologic conditions were present, in 2 people — neurologic signs.

In the examined group of patients with epiphora, we found that in 1.5–3 month after Coronavirus infection COVID-19 with anosmia, as a common sign of the disease in more than a half of cases, a development of pathological changes of the horizontal portion of lacrimal pathways was revealed.

About the authors

Nataliya Yu. Beldovskaya

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: beldovskay@mail.ru
ORCID iD: 0000-0001-9864-504X
SPIN-code: 8331-1449

MD, Cand. Sci. (Med.), Associate Professor, Yu.S. Astakhov Department of Ophthalmology with Clinic

Russian Federation, Saint Petersburg

Liliia K. Anikina

Academician I.P. Pavlov First St. Petersburg State Medical University

Author for correspondence.
Email: lily-sai@yandex.ru
ORCID iD: 0000-0001-8794-0457
SPIN-code: 3359-4587

Postgraduate Student

Russian Federation, Saint Petersburg

Galina V. Angelopoulo

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: nmaculova@yandex.ru

MD, Cand. Sci. (Med.), Associate Professor, Yu.S. Astakhov Department of Ophthalmology with Clinic

Russian Federation, Saint Petersburg

Anna Moroziuk

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: ana.moroziuk@gmail.com
ORCID iD: 0000-0002-2082-3341
SPIN-code: 7506-6597

Postgraduate Student, Yu.S. Astakhov Department of Ophthalmology with Clinic

Russian Federation, Saint Petersburg

References

  1. Yaguchi S, Ogawa Y, Shimmura S, et al. Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2012;53(9):5416–5425. doi: 10.1167/iovs.12-9891
  2. Giese MJ, Speth RC. The ocular renin-angiotensin system: a therapeutic target for the treatment of ocular disease. Pharmacol Ther. 2014;142(1):11–32. doi: 10.1016/j.pharmthera.2013.11.002
  3. Vaajanen A, Kalesnykas G, Vapaatalo H, Uusitalo H. The expression of Mas-receptor of the renin-angiotensin system in the human eye. Graefes Arch Clin Exp Ophthalmol. 2015;253(7):1053–1059. doi: 10.1007/s00417-015-2952-z
  4. Turgel VA, Antonov VA, Tultseva SN, et al. COVID-19 as a new risk factor for the development of acute vascular diseases of the optic nerve and retina. Ophthalmology Journal. 2021;14(2):105–115. (In Russ.) doi: 10.17816/OV64115
  5. www.who.int [Internet]. Osnovnye svedeniya o COVID-19. Available at: https://www.who.int/ru/news-room/questions-and-answers/item/coronaviruse-disease-covid-19 (In Russ.)
  6. Brzheskiy VV, Konikova OA, Sadovnikova NN, Efimova EL. Changes in the organ of vision in children and adults with confirmed COVID-19 and anti-epidemic measures. Russian ophthalmology of children. 2021;(3):44–53. (In Russ.) doi: 10.25276/2307-6658-2021-3-44-53
  7. Chen L, Liu M, Zhang Z, et al. Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol. 2020;104(6):748–751. doi: 10.1136/bjophthalmol-2020-316304
  8. Khavandi S, Tabibzadeh E, Naderan M, Shoar S. Corona virus disease-19 (COVID-19) presenting as conjunctivitis: atypically high-risk during a pandemic. Cont Lens Anterior Eye. 2020;43(3):211–212. doi: 10.1016/j.clae.2020.04.010
  9. Trufanov SV, Malozhen SA, Krakhmaleva DA, et al. Antiangiogenic therapy in high-risk keratoplasty. Vestnik Oftalmologii. 2020;136(4):1118. (In Russ). doi: 10.17116/oftalma202013604111
  10. Meduri A, Oliverio GW, Mancuso G, et al. Ocular surface manifestation of COVID-19 and tear film analysis. Sci Rep. 2020;10(1):20178. doi: 10.1038/s41598-020-77194-9
  11. Cheema M, Aghazadeh H, Nazarali S, et al. Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19). Can J Ophthalmol. 2020;55(4):e125–129. doi: 10.1016/j.jcjo.2020.03.003
  12. Guo D, Xia J, Wang Y, et al. Relapsing viral keratoconjunctivitis in COVID-19: A case report. Virol J. 2020;17:97. doi: 10.1186/s12985-020-01370-6
  13. Lan QQ, Zeng SM, Liao X. A special on epidemic prevention and control: screening for novel coronavirus related conjunctivitis among the patients with coronavirus disease 2019. Zhonghua Yan Ke Za Zhi. 2020;56(6):433–437. [In Chinese]. doi: 10.3760/cma.j.cn112142-20200322-00213
  14. Martínez Díaz M, Copete Piqueras S, Blanco Marchite C, Vahdani K. Acute dacryoadenitis in a patient with SARS-CoV-2 infection. Orbit. 2021;41(3):374–377. doi: 10.1080/01676830.2020.1867193
  15. Sen M, Honavar SG, Sharma N, Sachdev MS. COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19. Indian J Ophthalmol. 2021;69(3):488–509. doi: 10.4103/ijo.IJO_297_21
  16. Neroev VV, Krichevskaya GI, Balatskaya NV. COVID-19 and problems of ophthalmology. Russian Ophthalmological Journal. 2020; 13(4):99–104. (In Russ.) doi: 10.21516/2072-0076-2020-13-4-99-104
  17. Al-Namaeh M. COVID-19 and conjunctivitis: a meta-analysis. Ther Adv Ophthalmol. 2021;13:25158414211003368. doi: 10.1177/25158414211003368
  18. Brzheskii VV, Somov EE. Sindrom sukhogo glaza. Saint Petersburg: Apollon, 1998. 96 p. (In Russ.)
  19. Hu Y, Chen T, Liu M, et al. Positive detection of SARS-CoV-2 combined HSV1 and HHV6B virus nucleic acid in tear and conjunctival secretions of a non-conjunctivitis COVID-19 patient with obstruction of common lacrimal duct. Acta Ophthalmol. 2020;98(8):859–863. doi: 10.1111/aos.14456

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Distribution of patients with epiphora after COVID-19 with other symptoms and clinical signs

Download (119KB)
Indexing metadata
3. Fig. 2. A photo taken by the patient herself during the acute period of COVID-19 disease

Download (52KB)
Indexing metadata
4. Fig. 3. Orbital fat prolapses (case report 3)

Download (147KB)
Indexing metadata
5. Fig. 4. Photo of the patient’s right eye, 5 days after COVID-19 was diagnosed

Download (119KB)
Indexing metadata
6. Fig. 5. Formed tear points on the right eye

Download (161KB)
Indexing metadata
7. Fig. 6. The overgrowth of the lower lacrimal tubule: a — the general view of the right eye; b — the lower lacrimal point of the right eye (indicated by the arrow)

Download (159KB)
Indexing metadata

Copyright (c) 2022 Beldovskaya N.Y., Anikina L.K., Angelopoulo G.V., Moroziuk A.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies