Astrocytoma of the optic nerve head

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Abstract

In this article, a clinical case of astrocytoma of optic nerve head in patient with neurofibromatosis type 1 is presented. The main feature of this clinical case is a difficulty in differential diagnosis with amelanotic choroidal melanoma.

About the authors

Elena V. Goltsman

City Multi-Field Hospital No. 2

Email: ageeva_elena@inbox.ru

Ophthalmologist

Russian Federation, Saint Petersburg

Vitaly V. Potyomkin

Pavlov First Saint Petersburg State Medical University; City Multi-Field Hospital No. 2

Author for correspondence.
Email: potem@inbox.ru

PhD, Assistant Professor. Department of Ophthalmology; ophthalmologist

Russian Federation, Saint Petersburg

Yuriy S. Astakhov

Pavlov First Saint Petersburg State Medical University

Email: astakhov73@mail.ru

MD, Doctor of Medical Science, Professor, Department of Ophthalmology

Russian Federation, Saint Petersburg

Olga A. Marchenko

City Multi-Field Hospital No. 2

Email: oamarchenko@yandex.ru

Ophthalmologist

Russian Federation, Saint Petersburg

Vladimir A. Antonov

Pavlov First Saint Petersburg State Medical University

Email: antonov@alborada.fi

Resident, Department of Ophthalmo­logy

Russian Federation, Saint Petersburg

Anastasiya E. Kel’ina

North-Western State Medical University named after I.I. Mechnikov

Email: stokecity@bk.ru

student

Russian Federation, Saint Petersburg

References

  1. Бровкина А.Ф. Офтальмоонкология. Руководство для врачей. – М.: Медицина, 2002. [Brovkina AF. Oftal’moonkologiya. Rukovodstvo dlya vrachey. Moscow: Meditsina; 2002.(In Russ.)]
  2. Бровкина А.Ф. Дифференциальная диагностика меланомы хориоидеи // Офтальмологические ведомости. – 2008. – Т 1. – № 4. – С. 68–76. [Brovkina AF. Differential diagnosis of choroidal melanoma. Oftal’mologicheskie vedomosti. 2008;1(4):68-76. (In Russ.)]
  3. Dutton JJ. Gliomas of the anterior visual pathway. Surv Ophthalmol. 1994;38(5):427-452. https://doi.org/10.1016/0039-6257(94)90173-2.
  4. DeBustroas S, Miller NR, Finkelstein D, et al. Bilateral astrocytic hamartomas of the optic nerve heads in retinitis pigmentosa. Retina. 1983;3(1):21-23.
  5. Stumpf DA, Alksne JF, Annegers F, et al. NIH consensus development conference: neurofibromatosis conference statement. Arch Neurol. 1988;45:575-578.
  6. Listernick R, Ferner RE, Liu GT, Gutmann DH. Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations. Ann Neurol. 2007;61(3):189-198. https://doi.org/10.1002/ana.21107.
  7. Martyn LJ, Knox DL. Glial hamartoma of the retina in generalized neurofibromatosis, Von Recklinghausen’s disease. Br J Ophthalmol. 1972;56(6):487-491. https://doi.org/10.1136/bjo.56.6.487.
  8. Narayanan V. Tuberous sclerosis complex: genetics to pathogenesis. Pediatr Neurol. 2003;29(5):404-409. https://doi.org/10.1016/j.pediatrneurol.2003.09.002.
  9. Pusateri A, Margo CE. Intraocular astrocytoma and its differential diagnosis. Arch Pathol Lab Med. 2014;138(9):1250-1254. https://doi.org/10.5858/arpa.2013-0448-RS.
  10. Riccardi VM. Neurofibromatosis: past, present, and future. N Engl J Med. 1991;324(18):1283-1285. https://doi.org/10.1056/NEJM199105023241812.
  11. Recupero SM, Plateroti R, Abdolrahimzadeh S, et al. Lisch nodules in neurofibromatosis type 1: relationship to age and cutaneous neurofibromas. Annals of ophthalmology-glaucoma. 1996;28(3):178-183.
  12. Ragge NK, Falk RE, Cohen WE, Murphree AL. Images of Lisch nodules across the spectrum. Eye (Lond). 1993;7 (Pt 1):95-101. https://doi.org/10.1038/eye.1993.20.
  13. Shields JJ, Shields CL. Intraocular tumors: A text and atlas. Philadelphia, PA: WB Saunders Co; 1992.
  14. Ulbright TM, Fulling KH, Helveston EM. Astrocytic tumors of the retina. Differentiation of sporadic tumors from phakomatosis-associated tumors. Arch Pathol Lab Med. 1984;108(2): 160-163.

Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. Coffee with milk spots (arms and head) and dermal neurofibroma in patient with neurofibromatosis type 1

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3. Fig. 2. Astrocytoma of the optic nerve head. Black arrows demonstrate a lobular structure of the tumor

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4. Fig. 3. B-scan ultrasound of left eye. Tumor grows from optic nerve (white arrow) causing secondary retinal detachment

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5. Fig. 4. MRI of orbits. Intaocular tumor over the optic nerve

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6. Fig. 5. Astrocytoma of the optic nerve head in 56 year old man. Nodules of calcification are marked with black arrows, better visualization in red-free light

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7. Fig. 6. Amelanotic juxtapapillary choroidal melanoma penetrating Bruch’s membrane (black arrows). B-scan demonstrates deep choroidal excavation (white arrow)

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Copyright (c) 2019 Goltsman E.V., Potyomkin V.V., Astakhov Y.S., Marchenko O.A., Antonov V.A., Kel’ina A.E.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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