Email this article 
Post a Comment Сorneal endothelium after laser activation of trabecular meshwork in patients with primary open-angle glaucoma
- Authors: Yashina V.N.1, Sokolovskaya T.V.1, Volodin P.L.1
-
Affiliations:
- S. Fyodorov Eye Microsurgery Federal State Institution
- Issue: Vol 12, No 3 (2019)
- Pages: 7-11
- Section: Original researches
- URL: https://journals.rcsi.science/ov/article/view/10889
- DOI: https://doi.org/10.17816/OV10889
- ID: 10889
Cite item
Abstract
Background. Nowadays, laser surgery methods for glaucoma treatment gained wide use in clinical practice due to their efficacy, safety, and minimal risk of postoperative complications. In the scientific literature, data are presented on the effect of laser radiation on corneal endothelial cells that is why this aspect should be investigated when using new laser technologies in glaucoma treatment. One of the most modern methods of corneal examination is confocal microscopy, which allows visualizing corneal tissue at cellular level.
Purpose: to study the impact of laser radiation on the state of corneal endothelial cells in YAG-laser activation of trabecular meshwork in patients with primary open-angle glaucoma.
Materials and methods. Sixteen eyes of 15 patients were included in the analysis. The mean age of patients was 65.8 ± 5.35 years. In all patients, YAG-laser activation of trabecular meshwork was performed. At different follow-up terms (up to 6 months after laser surgery) the level of IOP was controlled, the state of corneal endothelium was studied using confocal microscopy.
Results. According to dynamic follow-up confocal microscopy results, no statistically significant difference between average density of endothelial cells, polymegathism, and pleomorphism have been identified (p > 0.05).
Conclusion. The study did not reveal any negative impact of YAG-laser activation of trabecular meshwork on the endothelium of the cornea, suggesting the safety of this technology.
Full Text
##article.viewOnOriginalSite##About the authors
Valeriya N. Yashina
S. Fyodorov Eye Microsurgery Federal State Institution
Author for correspondence.
Email: varlusha92@mail.ru
Postgraduate student
Russian Federation, 127486, Moscow, Beskudnikovskiy bulvar, 59aTatyana V. Sokolovskaya
S. Fyodorov Eye Microsurgery Federal State Institution
Email: dr.sokoltv@mail.ru
Ph.D., Leading Research Associate of Glaucoma Surgery Department
Russian Federation, 127486, Moscow, Beskudnikovskiy bulvar, 59aPavel L. Volodin
S. Fyodorov Eye Microsurgery Federal State Institution
Email: plvmd@yandex.ru
Med.Sc.D., Head of Retinal Laser Department
Russian Federation, 127486, Moscow, Beskudnikovskiy bulvar, 59aReferences
- Соколовская Т.В., Дога А.В., Магарамов Д.А., Кочеткова Ю.А. YAG-лазерная активации трабекулы в лечении больных первичной открытоугольной глаукомой // Офтальмохирургия. – 2014. – № 1. – С. 47–52. [Sokolovskaya TV, Doga AV, Magaramov DA, Kochetkova YA. Yag laser activation of trabecula in treatment of patients with primary open-angle glaucoma. Fyodorov Journal of Ophthalmic Surgery. 2014;(1):47-52. (In Russ.)]. doi: https://doi.org/10.25276/0235-4160-2014-1-47-52.
- Соколовская Т.В., Дога А.В., Магарамов Д.А., Кочеткова Ю.А. Лазерная активация трабекулы в лечении первичной открытоугольной глаукомы // Офтальмохирургия. № 1. – 2015. – С. 27–31. [Sokolovskaya TV, Doga AV, Magaramov DA, Kochetkova YA. Laser activation of trabecula in treatment of primary open-angle glaucoma. Fyodorov Journal of Ophthalmic Surgery. 2015;(1):27-31. (In Russ.)]. doi: https://doi.org/10.25276/0235-4160-2015-1-27-31.
- Latina MA, Sibayan SA, Shin DH, et al. Q-switched 532-nm Nd: YAG laser trabeculoplasty (selective laser trabeculoplasty). Ophthalmology. 1998;105(11):2082-2090. doi: https://doi.org/10.1016/s0161-6420(98)91129-0
- Нестеров А.П., Егоров Е.А., Новодережкин В.В. Лазерные способы гидродинамической активации оттока ВГЖ // РМЖ. Клиническая офтальмология. – 2005. – Т. 6. – № 1. – С. 16–17. [Nesterov AP, Egorov EA, Novoderezhkin VV. Lazernye sposoby gidrodinamicheskoy aktivatsii ottoka VGZh. RMZh. Klinicheskaya oftal’mologiya. 2005;6(1):16-17. (In Russ.)]
- Курышева Н.И., Рыжков П.К., Топольник Е.В., Капкова С.Г. Состояние эндотелия роговицы после селективной лазерной трабекулопластики // Глаукома. – 2012. – № 2. – С. 38–43. [Kurysheva NI, Ryzhkov PK, Topolnik EV, Kapkova SG. Corneal endothelium after selective laser trabeculoplasty. Glaukoma. 2012;(2):38-43. (In Russ.)]
- Ong K, Ong L, Ong LB. Corneal endothelial abnormalities after selective laser trabeculoplasty (SLT). J Glaucoma. 2015;24(4):286-290. doi: https://doi.org/10.1097/IJG.0b013e3182946381.
- Atalay K, Kirgiz A, Serefoglu Cabuk K, Erdogan Kaldirim H. Corneal topographic alterations after selective laser trabeculoplasty. Int Ophthalmol. 2017;37(4):905-910. doi: https://doi.org/10.1007/s10792-016-0348-7.
- Ornek N, Ornek K. Corneal endothelial changes following a single session of selective laser trabeculoplasty for pseudoexfoliative glaucoma. Int Ophthalmol. 2018;38(6):2327-2333. doi: https://doi.org/10.1007/s10792-017-0730-0.
- Leahy KE, Madigan MC, Sarris M, et al. Investigation of corneal endothelial changes post selective laser trabeculoplasty. Clin Exp Ophthalmol. 2018;46(7):730-737. doi: https://doi.org/10.1111/ceo.13172.
- Патент РФ на изобретение № 2281743/ 20.08.2006. Бюл. № 23. Магарамов Д.А., Дога А.В. Способ лазерной активации трабекулы для лечения первичной открытоугольной глаукомы. [Patent RUS No. 2281743/ 20.08.2006 Byul. No. 23. Magaramov DA, Doga AV. Sposob lazernoy aktivatsii trabekuly dlya lecheniya pervichnoy otkrytougol’noy glaukomy. (In Russ.)]
Supplementary files
