Disorganization of retinal inner layers: diagnostic and clinical characteristics

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Abstract

This review describes the current state of knowledge of the phenomenon of disorganization of retinal inner layers. DRIL is characterized by alteration of microcirculation in retinal capillary plexuses detected with optical coherence tomography angiography, alteration of several inner layers of the retina with the inability to differentiate them on optical coherence tomography, and by an impact on the quality of vision. Disorganization of retinal inner layers occurs in a number of different vascular retinal disorders, which indicates its importance as a clinical biomarker and clinical significance. However, the literature data on disorganization of retinal inner layers are still limited, and questions about the pathogenesis of this disease warrant further investigations.

About the authors

Maria A. Burnasheva

S.M. Kirov Military Medical Academy

Email: maria.andreevna1@gmail.com
ORCID iD: 0000-0001-7384-2223
SPIN-code: 5574-3595

Ophthalmologist

Russian Federation, Saint Petersburg

Alexei N. Kulikov

S.M. Kirov Military Medical Academy

Email: alexey.kulikov@mail.ru
ORCID iD: 0000-0002-5274-6993
SPIN-code: 6440-7706

MD, Dr. Sci. (Med.), Professor, Head of the Ophthalmology Department

Russian Federation, Saint Petersburg

Dmitrii S. Maltsev

S.M. Kirov Military Medical Academy

Author for correspondence.
Email: glaz.med@yandex.ru
ORCID iD: 0000-0001-6598-3982
SPIN-code: 4903-2333

MD, Dr. Sci. (Med.), Head of Medical Retina Division of Ophthalmology Department

Russian Federation, Saint Petersburg

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2. Fig. 1. Multimodal imaging of the left eye of a 65 year old female with diabetic retinopathy: a – cross-sectional scan through the center of the macula; b – cross-sectional optical coherence tomography scan through the area of DRIL (arrowheads); c – vessel density map of superficial capillary plexus; d – vessel density map of deep vascular complex. Note a more substantial loss of vessel density in superficial capillary plexus than in deep vascular complex; e – cross-sectional scan through the area of disorganization of inner retinal layers (arrowheads). Note the preservation of nerve fiber layer; f – distribution of flow signal within cross-sectional scan. The lesion (arrowheads) demonstrates flow void mostly in the inner and middle retinal layers while the innermost retinal vessels are preserved

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3. Fig. 2. Disorganization of retinal inner layers in 68 year old patient with severe non-proliferative diabetic retinopathy: a – scanning laser ophthalmoscopy with green light showing no acute ischemic lesions; b – fluorescein angiography showing a non-perfused area exactly corresponding to the disorganization of retinal inner layers; c – optical coherence tomography angiography projection of the superficial capillary plexus showing nonperfused areas of the retina. The dotted line shows the position of the scan in В; d – cross-sectional optical coherence tomography scan showing disorganization of retinal inner layers (arrowheads)

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Copyright (c) 2022 Burnasheva M.A., Kulikov A.N., Maltsev D.S.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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