The effect of chronic bile loss on the thyroid gland

The morphofunctional state of the parenchyma and the microcirculatory bed of the thyroid gland in chronic bile loss were studied. The studies were carried out on 25 cats of both sexes, in which external drainage of the common bile duct was performed from 5 to 40 days. After 7-10 days, pronounced hypertrophy and hyperplasia of the follicular epithelium were detected in the thyroid gland. Hyperplasia was extrafollicular in nature with the formation of numerous microfollicles. There was a statistically significant increase in the height of the follicular epithelium cells and a decrease in the average diameter of the follicles. On the 10th day of the experiment, the level of protein-bound iodine in serum was 0.29±0.03 °/o 131I per 1 liter of serum (Functional research methods in endocrinology. Kiev, Zdorov'ya, 1981), in the control - 0.34 ± 0.04%. Accumulation of 131I reached its maximum level after 6-10 hours.