On some features of the cultivation of Obermeier spirochetes

After the discovery by Schaudin, in 1905, of the causative agent of syphilis, naturally keen interest among bacteriologists raised the question of the cultivation of this spirochete. However, the difficulties that were encountered on the way of the first researchers (Kolpino and Fontana, Levaditi and Mc Intosh, Schereschewsk y, Hoffmann) in solving this problem forced the question of cultivating spirochetes in general to be put on the agenda. Therefore, it is not a mere coincidence that the first pure culture of the spirochete (Spir. Dentium) was obtained by Mühlen S'OM in 1906, that is, already a year after the discovery of the pale spirochete. However, mixed cultures of spirochetes (so-called Mischkultur) were obtained even earlier — Goadby B1903, Veszpémi, Walver and F unni with lif fʹ, Müll e r and Scherber in 1905. In 1909, Schereschewsky received a pale spirochete in a culture mixed with other bacteria, and in the same year, Mühlens, and a year later, Hoffmann announced that they had received a pure culture of this spirochete.