Clinical tolerance and metabolism of isoniazid in persons over 50 years of age
- Authors: Smirnov G.A.
- Issue: Vol 60, No 1 (1979)
- Pages: 25-28
- Section: Theoretical and clinical medicine
- URL: https://journals.rcsi.science/kazanmedj/article/view/58719
- DOI: https://doi.org/10.17816/kazmj58719
- ID: 58719
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Abstract
A study of the rate of inactivation of isoniazid in the body of patients of different ages found a slightly higher frequency of strong inactivation and a slightly lower amount of acetylation of the drug in persons over 50 years of age and in young men. The frequency of side effects of medium fractional doses of isoniazid in patients over 50 years old was the same as in middle-aged people. The elderly tolerated high fractional and single doses of the drug significantly worse.
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##article.viewOnOriginalSite##About the authors
G. A. Smirnov
Author for correspondence.
Email: info@eco-vector.com
Russian Federation
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