Epidemiological features and risk factors of non-scpecific low back pain in petrochemical enterprise workers
- Authors: Amirova TK.1, Gubanov RA2, Akhmetov II2, Egorova ES1, Khismatova ZF3, Fatkhutdinova LM1
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Affiliations:
- Kazan State Medical University
- Medical company «Spasenie»
- Volga Region State Academy of Physical Culture, Sports and Tourism
- Issue: Vol 97, No 1 (2016)
- Pages: 114-119
- Section: Social hygiene and healthcare management
- URL: https://journals.rcsi.science/kazanmedj/article/view/2376
- DOI: https://doi.org/10.17750/KMJ2016-114
- ID: 2376
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Full Text
Abstract
Aim. To study the prevalence and incidence of new cases, and the role of risk factors such as PARK2 gene polymorphism and mechanical loads in non-specific low back pain development in workers of a large petrochemical enterprise.
Methods. On a cross-sectional study by continuous sampling method (all factory workers - 580 people, the participation rate 87.6%) the prevalence of problems with the musculoskeletal system, including low-back pain was studied. Russian version of the Nordic questionnaire and the analysis of medical records were used. 228 people without any musculoskeletal system problems (the participation rate 82.4%) were selected for the 6-month prospective study. PARK2 gene rs926849 A/G polymorphism has been identified in 177 workers; epithelial cells of the oral cavity served as material for genetic analysis. The severity of the work process was evaluated in all workplaces. Multivariate statistical analysis was conducted by logistic regression method.
Results. The prevalence of low back pain reached 38.7%; the incidence of new cases at 6 months was 13.3%. In case of genotype AA of PARK2 gene rs926849 polymorphism (compared with protective genotypes AG and GG) the low back pain was more common (OR=1.68, p=0.047). Another risk factor was age (OR=1.06, p=0.005). The presence of the «work severity» variable in the model increased the level of statistical significance of the «genotype» variable from p=0.055 to p=0.047, i.e. the association with the risk of low back pain increased.
Conclusion. Hereditary predisposition and age play a significant role in the development of non-specific low back pain among workers; mechanical loads may increase the effect of a genetic predisposition, but do not have an independent etiologic importance.
About the authors
T Kh Amirova
Kazan State Medical University
Author for correspondence.
Email: zilek_85@mail.ru
R A Gubanov
Medical company «Spasenie»
Email: zilek_85@mail.ru
I I Akhmetov
Medical company «Spasenie»
Email: zilek_85@mail.ru
E S Egorova
Kazan State Medical University
Email: zilek_85@mail.ru
Z F Khismatova
Volga Region State Academy of Physical Culture, Sports and Tourism
Email: zilek_85@mail.ru
L M Fatkhutdinova
Kazan State Medical University
Email: zilek_85@mail.ru
References
- Арестов С.О., Гуща А.О., Кащеев А.А. Особенности техники и отдалённые результаты портальных эндоскопических вмешательств при грыжах межпозвонковых дисков пояснично-крестцового отдела позвоночника. Вопр. нейрохир. 2011; (1): 27-33.
- Исмагилов М.Ф., Галиуллин Н.И., Мингалеев Д.Р. Издержки современной практической неврологии. Неврол. вестн. 2005; XXXVII (1-2): 105-107.
- Кукшкин Л.М. Неспецифическая боль в низу спины. Рос. мед. ж. http://www.rmj.ru/articles_6935.htm (дата обращения: 05.04.2015).
- Насонова В.А. Боль в спине. Боль в нижней части спины - большая медицинская и социальная проблема, методы лечения. Consil. med. http://www.consilium-medicum.com (дата обращения: 21.03.2015).
- Якупов Р.Р., Каримова Л.К., Нафиков Р.Г. Дистрофические изменения опорно-двигательной системы у лиц физического труда. Гигиена и санитария. 2010; (4): 55-58.
- Balagué F., Mannion A.F., Pellisé F., Cedraschi C. Non-specific low back pain. Lancet. 2011; 378: 482-491. http://dx.doi.org/10.1016/S0140-6736(11)60610-7.
- Coenen P., Kingma I., Boot C.R. et al. Cumulative mechanical low-back load at work is a determinant of low-back pain. J. Occupat. Environment. Med. 2014; (5): 332-337. http://dx.doi.org/10.1136/oemed-2013-101862.
- Eskola P.J., Lemmelä S., Kjaer P. et al. Genetic association studies in lumbar disc degeneration: a systematic review. PLoS One. 2012; (7): e49995. http://dx.doi.org/10.1371/journal.pone.0049995.
- Izzo R., Popolizio T., D’Aprile P., Muto M. Spinal pain. Eur. J. Radiol. 2015; 84 (5): 746-756. http://dx.doi.org/10.1016/j.ejrad.2015.01.018.
- Kay D.M., Stevens C.F., Hamza T.H. et al. A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2. Neurology. 2010; 75: 1189-1194. http://dx.doi.org/10.1212/WNL.0b013e3181f4d832.
- Kuorinka I., Jonsson B., Kilbom A. et al. Standardized Nordic questionnaires for the analysis of musculoskeletal symptoms. J. Appl. Ergonom. 1987; 18: 233-237. http://dx.doi.org/10.1016/0003-6870(87)90010-X
- Shils M.E., Shike M., Ross A.C. et al. Modern nutrition in health and disease. 10th ed. Baltimore: Lippincott, Williams & Wilkins. 2006; 214 p.
- Punnett L., Prüss-Utün A., Nelson D.I. et al. Estimating the global burden of low back pain attributable to combined occupational exposures. Am. J. Industr. Med. 2005; 48: 459-469. http://dx.doi.org/10.1002/ajim.20232.
- Williams F.M., Bansal A.T., van Meurs J.B. et al. Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. Ann. Rheum. Dis. 2013; 7: 1141-1148. http://dx.doi.org/10.1136/annrheumdis-2012-201551.