Statherin saliva levels in patients with dental caries
- Authors: Yavgil’dina DA1, Saleev RA1
-
Affiliations:
- Kazan State Medical University, Kazan, Russia
- Issue: Vol 95, No 5 (2014)
- Pages: 654-657
- Section: Theoretical and clinical medicine
- URL: https://journals.rcsi.science/kazanmedj/article/view/2210
- DOI: https://doi.org/10.17816/KMJ2210
- ID: 2210
Cite item
Full Text
Abstract
Aim. To examine the influence of statherin on the rate of dental diseases and to determine the concentration of salivary staterin in patients with dental caries. Methods. The study recruited 134 persons, including 54 patients with dental caries and its complications (experimental group) and 80 healthy volunteers (control group). Pateints’ mean age ranged from 18 to 42 years. A comprehensive dental examination of all subjects was carried out, hygiene indexes were defined, complete dental history was gathered. Whole unstimulated saliva was examined. Statherin saliva level was determined using an enzyme-linked immunoassay test. To study the relationship between statherin saliva level and studied dental clinical features (amount of teeth with caries, sealed and extracted teeth, age, hygiene indices, eating and smoking habits, xerostomia), Spearman nonparametric rank correlation test was used. Results. Statherin saliva level was higher in patients with dental caries and its complications compared to healthy controls. Mean saliva statherin concentration was Me=6.1 [2.5, 18.4] mmol/l in patients with caries compared to Me=3.5 [2.9, 7.3] mmol/l in control group. There was no statistically significant differences of saliva staterin concentrations between men and women in both groups. Oral hygiene (as defined by simplified oral hygiene index), food consumption (right after a meal or 4 hours after a meal), bad habits (smoking) had no effect on statherin concentrations in saliva. Conclusions. Statherin saliva levels are indicative of the diseases of the oral cavity.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
D A Yavgil’dina
Kazan State Medical University, Kazan, Russia
Email: dinarochka@inbox.ru
R A Saleev
Kazan State Medical University, Kazan, Russia
References
- Денисов А.Б., Стурова Т.М. Роль белков слюны в формировании зубного налёта // Форум стоматол. (Dental Forum). - 2009. - №3 (31). - С. 45-53. [A.B. Denisov, T.M. Sturova. Role of saliva proteins in dental plaque formation. Dental Forum. 2009; 3 (31); 45-53. (In Russ.)]
- Haigh B.J., Stewart K.W., Whelan J.R.K. et al. Alterations in the salivary proteome associated with periodontitis // J. Clin. Periodontol. - 2010. - Vol. 37, issue 3. - P. 241-247.
- Isola M., Cabras T., Inzitari R. et al. Electron microscopic detection of statherin in secretory granules of human major salivary glands // J. Anatom. - 2008. - Vol. 212, issue 5. - P. 664-668.
- Niemi L.D., Johansson I. Salivary statherin peptide-binding epitopes of commensal and potentially infectious Actinomyces spp. delineated by a hybrid peptide construct // Infect. Immun. - 2004. - Vol. 72, issue 2. - P. 782-787.
- Shimotoyodome A., Kobayashi H., Tokimitsu I. et al. Statherin and histatin 1 reduce parotid saliva-promoted Streptococcus mutans strain MT8148 adhesion to hydroxyapatite surfaces // Caries Research. - 2006. - Vol. 40, issue 5. - P. 403-411.