Pathogenetic treatment of the patient with splenic marginal zone lymphoma complicated by Evans syndrome
- Authors: Romanenko NA1, Bessmeltsev SS1, Abdulkadyrov KM1
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Affiliations:
- Russian Scientific and Research Institute of Hematology and Transfusiology, Saint-Petersburg, Russia
- Issue: Vol 93, No 5 (2012)
- Pages: 843-846
- Section: Clinical observations
- URL: https://journals.rcsi.science/kazanmedj/article/view/1726
- DOI: https://doi.org/10.17816/KMJ1726
- ID: 1726
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Abstract
A case report of a patients with splenic marginal zone lymphoma, in whom clinical remission was initially achieved by 5 continuous courses of combined treatment with fludarabine 25 mg/m2 and cyclophosphamide 350 mg/m2 at days 1-3. Nevertheless, 6 months after patient developed a clinical picture of Evans syndrome, characterized by severe hemolytic anemia, thrombocytopenia and neutropenia. Corticosteroid treatment accompanied by blood transfusion was initiated, the effect was marginal and short-lasting. Switch to rituximab monotherapy allowed to archieve complete clinical and hematological remission with full blood count parameters reversal.
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##article.viewOnOriginalSite##About the authors
N A Romanenko
Russian Scientific and Research Institute of Hematology and Transfusiology, Saint-Petersburg, Russia
Email: rom-nik@yandex.ru
S S Bessmeltsev
Russian Scientific and Research Institute of Hematology and Transfusiology, Saint-Petersburg, Russia
K M Abdulkadyrov
Russian Scientific and Research Institute of Hematology and Transfusiology, Saint-Petersburg, Russia
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