Prospective analysis of lipid profile parameters, inflammatory response and endothelial function markers before and after percutaneus coronary intervention in patients with stable angina

Cover Page

Cite item

Full Text

Abstract

Aim. To conduct the prospective study assessing the biochemical laboratory parameters in patients with stable angina and hemodynamically significant coronary artery stenosis before and 12 months after transluminal balloon-catheter angioplasty. Methods. 40 patients (males and females), mean age 57,3±9,6 years with stable angina and chronic coronary artery disease were examined. Patients were divided into 2 groups based on the absence (1st group, 14 patients) or presence (2st group, 26 patients) of hemodynamically significant coronary artery stenosis on selective coronary angiography. Patients with hemodynamically significant coronary artery stenosis underwent percutaneous transluminal coronary angioplasty (PTCA) with stenting (drug-coated stents). Blood lipid profile, inflammatory markers and endothelial dysfunction markers were measured before the surgery and 12 months after treatment. Results. In patients with hemodynamically significant coronary artery stenosis statistically significant association of hemodynamically significant coronary artery stenosis presence with atherogenic lipid fractions levels, inflammatory markers (high-sensitivity C-reactive protein, tumor necrosis factor-alpha) and an endothelial function parameter (endothelin-1) were revealed. Long-term results of PTCA with stenting included the significant decrease of atherogenic and increase of anti-atherogenic fractions in lipid profile. There also was a prolonged inflammatory response characterized by high-sensitivity C-reactive protein (hs-CRP) level elevation, and the endothelin system dysfunction retaining. Conclusion. Persistent hs-CRP level increase as well as endothelin-1 level increase suggest a high risk of late stent thrombosis, it should be taken into account while following-up patients at the late stages after PTCA.

About the authors

T I Petelina

Tyumen Cardiology Center, Tyumen, Russia

Email: petelina@cardio.tmn.ru

N A Musikhina

Tyumen Cardiology Center, Tyumen, Russia

L I Gapon

Tyumen Cardiology Center, Tyumen, Russia

N V Dementjeva

Tyumen Cardiology Center, Tyumen, Russia

References

  1. Верткин А.Л., Прохорович Е.А., Кульниченко Т.В. Роль статинов в лечении больных с острым коронарным синдромом без подьёма сегмента ST // Рус. мед. ж. - 2010. - №22. - С. 1315.
  2. Тепляков А.Т., Рыбальченко Е.В., Аптекарь В.Д. и др. Рецидивы стенокардии после стентирования коронарных артерий: влияние дислипидемии // Бюлл. СО РАМН. - 2006. - №1. - С. 13-17.
  3. Шишкин В.В., Поляков А.Е. С-реактивный белок как прогностический фактор у больных с ишемической болезнью сердца // Украiн. кардiол. ж. - 2006. - №1. - С. 14-17.
  4. Церетели Н.В., Рахимов А.З. Изменение параметров воспалительного ответа и показателей эндотелиальной функции после коронарного стентирования у больных ИБС // Вестн. Рос. академ. мед. наук (CD -приложение). - 2008. - №6. - С. 462.
  5. Berliner J.A., Haberland M.E. The role of oxidized low-density lipoprotein in atherogenesis // Curr. Opin. Lipidol. - 2003. - Vol. 4. - P. 373-381.
  6. Bhakdi S., Torzewski M., Klouche M., Hemmes M. Complement and atherogenesis. Binding of CRP to degraded, nonoxidized LDL enhances complement activation // Arterioscler. Thromb. Vasc. Biol. - 1999. - Vol. 19. - P. 2348-2354.
  7. Discepolo W., Wun T., Berglund L. Lipoprotein (a) and thrombocytes: potential mechanisms underlying cardiovascular risk // Pathophysiol. Haemost. Thromb. - 2006. - Vol. 35. - Р. 314-321.
  8. Erbel R., Ge J., Bockisch A. et al. Value of intracoronary ultrasound and Doppler in the differentiation of angiographically normal coronary arteries: a prospective study in patients with angina pectoris // Eur. Heart J. - 1996. - Vol. 17. - P. 880-889.
  9. Lipids and vacular disease. Current issues / D.J. Betteridge eds. - Martin Dunitz Ltd, 2000. - P. 85-105.
  10. Memon L., Spasojevic-Kalimanovska V., Bogavac-Stanojevic N. et al. Association of C-reactive protein with the presense and extent of angiographically verified coronary artery disease // Tohoku J. Exp. Med. - 2006. - Vol. 209. - P. 197-206.
  11. Pasceri V., Chang J., Willwrson J.T. et al. Modulation of C-reactive protein-mediated monocytechemoattractant protein-1 induction in human endothelial cells by antiaterosclerosis drugs // Circulation. - 2001. - Vol. 103. - P. 2531-2534.
  12. Ribichini F., Steffenino G., Dellavalle A. et al. On line quantitative coronary analysis in clinical practice: one step closer to reality? // Cathet. Cardiovasc. Diagn. - 1994. - Vol. 31. - P. 100-102.
  13. Stein J.H., Rosenson R.S. Lipoprotein Lp (a) excess and coronary heart disease // Arch. Int. Med. - 1997. - Vol. 157. - P. 1170-1176.
  14. Tanowitz H.B., Huang H., Jelicks L.A. et al. Role of endothelin-1 in the pathogenesis of chronic chagasic heart disease // Infect. Immun. - 2005. - Vol. 73. - P. 2496-2503.
  15. Voge R.A. Coronary risk factors, endothelial function, and atherosclerosis: a review // Clin. Cardiol. - 1997. - Vol. 20, N 5. - P. 426-432.

© 2012 Petelina T.I., Musikhina N.A., Gapon L.I., Dementjeva N.V.

Creative Commons License

This work is licensed
under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.




This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies