Bile acids serum levels in patients with nonalcoholic fatty liver disease
- Authors: Minnullina ZS.1, Kiyashko SV2, Ryzhkova OV3, Sayfutdinov RG1,3
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Affiliations:
- Kazan State Medical Academy, Kazan, Russia
- Center of Hygiene and Epidemiology in the Republic of Tatarstan, Kazan, Russia
- Medical and sanitary unit of JSC «Tatneft» and the city of Almetyevsk, Almetyevsk, Russia
- Issue: Vol 96, No 3 (2015)
- Pages: 354-358
- Section: Theoretical and clinical medicine
- URL: https://journals.rcsi.science/kazanmedj/article/view/1664
- DOI: https://doi.org/10.17750/KMJ2015-354
- ID: 1664
Cite item
Full Text
Abstract
Aim. To estimate the blood levels of primary, secondary, tertiary and unconjugated bile acids in patients with non-alcoholic fatty liver disease.
Methods. The study included 74 patients with non-alcoholic fatty liver disease (males - 30, females - 44) and 51 healthy individuals (males - 14, females - 37). All patients underwent anthropometry and complete clinical, biochemical and instrumental examination (measuring the subcutaneous fat layer). 64 patients had hepatic steatosis, 10 - steatohepatitis. Serum levels of bile acids (primary: cholic, chenodeoxycholic; secondary: lithocholic, deoxycholic and tertiary: ursodeoxycholic) were measured by gas-liquid chromatography on «Chromos GC-1000» (Russia) scanner.
Results. Unconjugated primary, secondary and tertiary bile acids were detected in the blood of healthy individuals and patients with non-alcoholic fatty liver disease. In healthy individuals, there were no gender differences found in the bile acids levels. Patients with non-alcoholic fatty liver disease had higher level of bile acids compared to healthy controls. There was a significant difference in the concentrations of secondary and tertiary bile acids in patients with hepatic steatosis and steatohepatitis.
Conclusion. Blood bile acids levels were significantly higher in patients with non-alcoholic fatty liver disease than in healthy individuals. At steatohepatitis, females had higher levels of cholic, chenodeoxycholic and deoxycholic acids and lower levels of lithocholic and ursodeoxycholic acids compared to males. Significant difference in patients with hepatic steatosis and steatohepatitis was revealed only in levels of secondary and tertiary bile acids.
About the authors
Z Sh Minnullina
Kazan State Medical Academy, Kazan, Russia
Author for correspondence.
Email: zukhra-minnullina@yandex.ru
S V Kiyashko
Center of Hygiene and Epidemiology in the Republic of Tatarstan, Kazan, Russia
Email: zukhra-minnullina@yandex.ru
O V Ryzhkova
Medical and sanitary unit of JSC «Tatneft» and the city of Almetyevsk, Almetyevsk, Russia
Email: zukhra-minnullina@yandex.ru
R G Sayfutdinov
Kazan State Medical Academy, Kazan, Russia; Medical and sanitary unit of JSC «Tatneft» and the city of Almetyevsk, Almetyevsk, Russia
Email: zukhra-minnullina@yandex.ru
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