Influence of a single-nucleotide polymorphism of AKT1 (rs2498796) and HEY2 (rs13328928) genes on the risk of endometrial cancer in women of the Republic of Tatarstan
- Authors: Gabidullina RI1, Nukhbala FR1, Smirnova GA2, Orlova Y.I1, Shakirov AA1, Valeeva EV1, Akhmetzyanova AF3, Fakhrutdinova GR3
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Affiliations:
- Kazan State Medical University
- City Clinical Hospital No. 7
- Tatarstan Regional Clinical Cancer Center
- Issue: Vol 100, No 5 (2019)
- Pages: 769-773
- Section: Theoretical and clinical medicine
- URL: https://journals.rcsi.science/kazanmedj/article/view/16319
- DOI: https://doi.org/10.17816/KMJ2019-769
- ID: 16319
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Abstract
Aim. To analyze the prevalence of different polymorphisms of AKT1 gene (rs2498796) and HEY2 gene (rs13328928) and to determine the association of revealed polymorphisms with the risk of endometrioid carcinoma in women living in the Republic of Tatarstan.
Methods. 161 female citizens of Tatarstan were enrolled. The study group included 60 patients with endometrial cancer (endometrioid carcinoma) and the control group enrolled 101 women without endometrial pathology. The age of the subjects ranged from 41 to 91 years. The single-nucleotide polymorphism of AKT1 gene (rs2498796) and HEY2 gene (rs13328928) was determined by real-time polymerase chain reaction. We ran a χ2 test and evaluated the odds ratio.
Results. The risk of endometrial cancer was higher in carriers of homozygous T/T genotype of AKT1 gene (rs2498796) without statistical significance (OR=1.61, 95% CI=0.61–4.21, p=0.62). Homozygous C/C genotype of HEY2 gene (rs13328928) with the mutant allele C was observed in endometrial cancer group with a frequency of 0.383 and 0.287 in the control group (χ2=1.70, p=0.43). The risk of endometrial cancer was higher in the group of homozygous C/C genotype without statistical significance (OR=1.54, 95% CI=0.79–3.03, p=0.43).
Conclusion. Among 161 females citizens of the Republic of Tatarstan included into the study, the associations of the mutant alleles of AKT1 gene (rs2498796) and HEY2 gene (rs13328928) with the risk of endometrial cancer were not identified; the prevalence of alleles and genotypes was found to be comparable with the European one.
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##article.viewOnOriginalSite##About the authors
R I Gabidullina
Kazan State Medical University
Author for correspondence.
Email: ru.gabidullina@yandex.ru
SPIN-code: 3091-2151
Russian Federation, Kazan, Russia
F R Nukhbala
Kazan State Medical University
Email: ru.gabidullina@yandex.ru
Russian Federation, Kazan, Russia
G A Smirnova
City Clinical Hospital No. 7
Email: ru.gabidullina@yandex.ru
Russian Federation, Kazan, Russia
Yu I Orlova
Kazan State Medical University
Email: ru.gabidullina@yandex.ru
Russian Federation, Kazan, Russia
A A Shakirov
Kazan State Medical University
Email: ru.gabidullina@yandex.ru
Russian Federation, Kazan, Russia
E V Valeeva
Kazan State Medical University
Email: ru.gabidullina@yandex.ru
Russian Federation, Kazan, Russia
A F Akhmetzyanova
Tatarstan Regional Clinical Cancer Center
Email: ru.gabidullina@yandex.ru
Russian Federation, Kazan, Russia
G R Fakhrutdinova
Tatarstan Regional Clinical Cancer Center
Email: ru.gabidullina@yandex.ru
Russian Federation, Kazan, Russia
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