A case of arterial thrombosis with formation of an atypical fibrin-rich thrombus
- Authors: Khismatullin RR1, Shakirova AZ1,2, Peshkova AD3, Khuziakhmedov AN4, Khizriev SM4, Litvinov RI3,5
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Affiliations:
- Kazan State Medical University
- Departmental Clinical Hospital of Station Kazan
- Kazan (Volga Region) Federal University
- City Clinical Hospital № 7
- University of Pennsylvania School of Medicine
- Issue: Vol 99, No 6 (2018)
- Pages: 994-997
- Section: Clinical observations
- URL: https://journals.rcsi.science/kazanmedj/article/view/10518
- DOI: https://doi.org/10.17816/KMJ2018-994
- ID: 10518
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Abstract
Aim. To describe a case of arterial thrombosis with a thrombus that had atypical composition due to profound pathological changes in the cellular and protein composition of the blood.
Methods. Scanning electron microscopy of an ex vivo thrombus extracted from the common femoral artery.
Results. In the absence of platelets and leukocytes there was a significant prevalence of fibrin over other blood components in all layers of the arterial thrombus. There were no morphological signs of intravital contraction (retraction) characteristic for thrombi: single erythrocytes were not exposed compressive deformation, redistribution of fibrin and platelets within the thrombus toward the periphery. Formation of the atypical arterial thrombus in the vessel with atherosclerotic vessel damage is probably due to association with severe hyperfibrinogenemia and thrombocytopenia.
Conclusion. The structure of a thrombus depends not only on its vascular location (arterial or venous), but also on the cellular and protein composition of the blood. These factors support diversification of antithrombotic therapy, considering composition and properties of thrombi irrespective of the place and hemodynamic conditions of their formation.
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##article.viewOnOriginalSite##About the authors
R R Khismatullin
Kazan State Medical University
Author for correspondence.
Email: rafael.khismatullin@gmail.com
Kazan, Russia
A Z Shakirova
Kazan State Medical University; Departmental Clinical Hospital of Station Kazan
Email: rafael.khismatullin@gmail.com
Kazan, Russia; Kazan, Russia
A D Peshkova
Kazan (Volga Region) Federal University
Email: rafael.khismatullin@gmail.com
Kazan, Russia
A N Khuziakhmedov
City Clinical Hospital № 7
Email: rafael.khismatullin@gmail.com
Kazan, Russia
S M Khizriev
City Clinical Hospital № 7
Email: rafael.khismatullin@gmail.com
Kazan, Russia
R I Litvinov
Kazan (Volga Region) Federal University; University of Pennsylvania School of Medicine
Email: rafael.khismatullin@gmail.com
Kazan, Russia; Philadelphia, USA
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