On the tolerability of high doses of tubazid in patients with pulmonary tuberculosis

In an effort to improve the effectiveness of treatment of tuberculosis patients, clinicians have been increasingly using increased therapeutic doses of GINK drugs in recent years. Many researchers, both in experimental and clinical observations, have found the advantage of high doses of tubazide over low ones [8, 10, 11], In this regard, there has been a tendency to use tubazide 0.3 three times, i.e. 15-20 mg/kg, even in broad clinical practice. Meanwhile, such a dose in the world literature is considered high, often leading to toxic reactions. Based on the materials of Biehl and co. (1954), Costelletos and co. (1954), Benda and co. (1954), a side effect when using isoniazid at a dose of 16-24 mg / kg is observed in 28-44% of cases. At the same time, the data on the therapeutic advantage of high doses cannot yet be considered indisputable, since there is a message about the absence of an additional effect with an increase in the amount of the drug administered [7]. The purpose of this study was to study the nature and frequency of side effects of tubazide, used 0.3 3 times a day, compared with average doses and the possibility of preventing toxic-allergic reactions with pyridoxine. There were 807 patients with fresh and chronic forms of pulmonary tuberculosis under observation (age - from 18 to 68 years). 210 people received tubazid 0.15 3 times a day and 597 - 0.3 3 times a day in combination with other tuberculostatic agents of the I or II series. Some patients receiving high doses of tubazide were given pyridoxine to prevent side effects.