电邮这篇文章 Hypothyroidism and early fetal demise
- 作者: Olina A.A.1
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隶属关系:
- Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- 期: 卷 67, 编号 3 (2018)
- 页面: 49-54
- 栏目: Articles
- URL: https://journals.rcsi.science/jowd/article/view/9085
- DOI: https://doi.org/10.17816/JOWD67349-54
- ID: 9085
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Background. The study is devoted to the evaluation of thyroid status in patients with early fetal demise.
The aim of the study was to assess the prevalence of hypothyroidism, including its subclinical forms, in patients with early fetal demise.
Materials and methods. It is an observational “case-control” retrospective study. Group I is represented by first-pregnant women with physiological on-time delivery of the healthy child (375 people). Group II consisted of 375 women who had had an episode of early fetal demise for up to 14 weeks. Laboratory and instrumental methods included assessment of TSH and anti-TPO antibodies levels and ultrasound imaging of the thyroid gland.
Results. Given TSH levels > 2.5 mU/L, the diagnosis of subclinical hypothyroidism was established in 13.1% of patients in group I and 26.4% in group II. In patients with repeated early fetal demise, the morbidity reached 48.4%.
Conclusion. Hypothyroidism can be recognized as a risk factor for early fetal demise (both the first and subsequent episodes) based on the odds ratio calculation. The odds ratio was 2.48 for early fetal demise in the presence of subclinical hypothyroidism and 2.15 for repeat episodes.
作者简介
Anna Olina
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
编辑信件的主要联系方式.
Email: olina29@mail.ru
MD, PhD, DSci (Medicine), Deputy Director for Developmen
俄罗斯联邦, Saint Petersburg参考
- Зайдиева Я.З. Беременность при заболеваниях щитовидной железы // Медицинский алфавит. - 2017. - № 1 (3). - C. 31-38. [Zaydieva YaZ. Pregnancy in thyroid diseases. Medical Alphabet. 2017;(1(3)):31-8. (In Russ.)]
- Луценко Л.А. Патология щитовидной железы у женщин репродуктивного возраста: преконцепционная подготовка и тактика ведения // Международный эндокринологический журнал. - 2015. - № 2 (66). - C. 111-116. [Lutsenko L A. Thyroid Disease in Women of Reproductive Age: Preconception Preparation and Management during Pregnancy. International Journal of Endocrinology. 2015;(2(66)):111-6. (In Russ.)]
- Аликенова Л.З., Еспенбетова М.Ж., Амренова К.Ш., Амангельдинова С.Б. Особенности функции щитовидной железы во время беременности // Наука и здравоохранение. - 2015. - № 1. - C. 13-21. [Alikenova LZ, Espenbetova MZh, Amrenova KSh, Amangel’dinova SB. Features of the thyroid gland function during pregnancy. Science and Health. 2015;(1):13-21. (In Russ.)]
- Радзинский В.Е. Прегравидарная подготовка: клинический протокол. - М.: StatusPraesens, 2016. [Radzinskij VE. Pregravidarnaja podgotovka: klinicheskij protokol. Мoskow: StatusPraesens; 2016. (In Russ.)]
- Alexander EK, Pearce EN, Brent GA, et al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017;27(3):315-389. doi: 10.1089/thy.2016.0457.
- Фадеев В.В. По материалам клинических рекомендаций по диагностике и лечению заболеваний щитовидной железы во время беременности и в послеродовом периоде американской тиреоидной ассоциации. Клиническая и экспериментальная тиреодология. - 2012. - № 8 (1). - С. 7-18. [Fadeyev VV. The use of L-T4 + L-T3 in the treatment of hypothyroidism:guidelines of the European Thyroid Association. Clinical and experimental thyroidology. 2012;8(1):7-18. (In Russ.)]
- Лебедева-Несевря Н.А. Социальные факторы риска здоровью как объект управления // Вестник Пермского университета. Серия «Биология». - 2010. - № 3. - C. 36-41. [Lebedeva-Nesevrja NA. Social’nye faktory riska zdorov’ju kak ob’ekt upravlenija. Vestnik Permskogo universiteta. Serija “Biologija”. 2010;(3):36-41. (In Russ.)]
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