Email this article Immunomorphological condition of placentas in women with repeated pregnancy losses under action of different antigens
- Authors: Zubgitskya L.B.1,2, Kosheleva N.G.1,2, Arganova O.N.1,2, Bespalova T.P.1,2, Gromiko G.L.1,2, Shapovalova Е.А.1,2, Tishkevich О.V.1,2
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Affiliations:
- Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- State Medical University named after acad. I.P. Pavlova
- Issue: Vol 51, No 2 (2002)
- Pages: 43-49
- Section: Scientific activity
- URL: https://journals.rcsi.science/jowd/article/view/90390
- DOI: https://doi.org/10.17816/JOWD90390
- ID: 90390
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Abstract
The aim of the research was to investigate the pathomorphological changes in placentas of women with recurrent pregnancy losses under action of different injuring stimulus (infection, hormonal, biochemical reactions on membrans of syncytiotrophoblast and endothelium of placental vessels, actions of antiphospholipid antibodies). Identical changes was detected which connected with immune complexes (IC) formation. IC with different composition generate immunopathological processes in placental tissues. Present of antiphospholipid antibodies on placental membranes enhancing immunopathological processes, leading to dystrophic and necrotic lesions in surrounding tissues and to placental insufficiency. The outcome of this lesions is incompetent pregnancy.
Therefore IC may be the marker of placental injury and insufficiency as well as a biologic indicator of failure in reproductive system.
The treatment of threatened abortion is improve pregnancy outcomes and immunomorphological evidence.
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##article.viewOnOriginalSite##About the authors
L. B. Zubgitskya
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; State Medical University named after acad. I.P. Pavlova
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Saint-Petersburg; Saint-Petersburg
N. G. Kosheleva
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; State Medical University named after acad. I.P. Pavlova
Email: info@eco-vector.com
Russian Federation, Saint-Petersburg; Saint-Petersburg
O. N. Arganova
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; State Medical University named after acad. I.P. Pavlova
Email: info@eco-vector.com
Russian Federation, Saint-Petersburg; Saint-Petersburg
T. P. Bespalova
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; State Medical University named after acad. I.P. Pavlova
Email: info@eco-vector.com
Russian Federation, Saint-Petersburg; Saint-Petersburg
G. L. Gromiko
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; State Medical University named after acad. I.P. Pavlova
Email: info@eco-vector.com
Russian Federation, Saint-Petersburg; Saint-Petersburg
Е. А. Shapovalova
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; State Medical University named after acad. I.P. Pavlova
Email: info@eco-vector.com
Russian Federation, Saint-Petersburg; Saint-Petersburg
О. V. Tishkevich
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; State Medical University named after acad. I.P. Pavlova
Email: info@eco-vector.com
Russian Federation, Saint-Petersburg; Saint-Petersburg
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